Diagnostic Role of Chromosomal Instability in Melanoma

Table 1

Common chromosomal aberrations found in specific melanoma subtypes [8, 23, 24].

Subtype of melanoma	Common chromosomal aberrations		Statistically significant chromosomal aberrations
	Gains	Losses	Gains	Losses
Superficial spreading, nonchronic sun exposure	6p, 7, 8q, 17q, 20q [23]	10q22.1, 10pter [8], 9p, 10q, 21q [23]		10q* [23]
Lentigo maligna, chronic sun exposure	17pter, 15q21.1, 15q15 [8], 6p, 11q13, 17q, 20q [23], 4q12 [24]	13q21.1, 17qter, 17pter [8], 6q, 8p, 9p, 13, 21q [23]
Acral	12q14, 5pter, 11q13, 4q11 [8], 6p, 7, 8q, 17q, 20q, 5p15, 5p13, 11q13, 12q14 [23], 4q12 [24]	15q13, 16q24, 16q23.1 [8], 6q, 9p, 10q, 11q, 21q [23]	12q14, 5pter [8], 69, 11q13 [23]	10q* [23]
Mucosal	1q, 6p, 7, 8q, 11q13, 17q, 20q, 1q31, 4q12, 12q14 [23], 4q12 [24]	3q, 4q, 6q, 8p, 9p, 10q, 11p, 11q, 21q [23]	1q, 6p, 11q13, 17q, 12q14 [23]	3q, 8p, 10q*, 11p [23]

*The losses in 10q were significant compared to melanomas from chronic sun exposed skin.