About this Journal Submit a Manuscript Table of Contents 
Journal of Skin Cancer
Volume 2012 (2012), Article ID 981308, 13 pages
http://dx.doi.org/10.1155/2012/981308
Research Article

Genome-Wide Analysis of Gene and Protein Expression of Dysplastic Naevus Cells

Linda Gao,1 Frans A. van Nieuwpoort,1 Jacoba J. Out-Luiting,1 Paul J. Hensbergen,2 Femke A. de Snoo,3 Wilma Bergman,1 Remco van Doorn,1 and Nelleke A. Gruis1

1Department of Dermatology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands
2Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
3Center for Human and Clinical Genetics, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands

Received 9 August 2012; Revised 10 October 2012; Accepted 11 October 2012

Academic Editor: Lionel Larue

Copyright © 2012 Linda Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Seykora and D. Elder, “Dysplastic nevi and other risk markers for melanoma,” Seminars in Oncology, vol. 23, no. 6, pp. 682–687, 1996. View at Google Scholar · View at Scopus
  2. J. S. Schneider, D. H. Moore, and R. W. Sagebiel, “Risk factors for melanoma incidence in prospective follow-up: the importance of atypical (dysplastic) nevi,” Archives of Dermatology, vol. 130, no. 8, pp. 1002–1007, 1994. View at Publisher · View at Google Scholar · View at Scopus
  3. M. H. Green, W. H. Clark, and M. A. Tucker, “Acquired precursors of cutaneous malignant melanoma. The familial dysplastic nevus syndrome,” New England Journal of Medicine, vol. 312, no. 2, pp. 91–97, 1985. View at Google Scholar · View at Scopus
  4. W. H. Clark, D. E. Elder, and D. Guerry, “A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma,” Human Pathology, vol. 15, no. 12, pp. 1147–1165, 1984. View at Google Scholar · View at Scopus
  5. A. R. Rhodes, Y. Seki, T. B. Fitzpatrick, and R. S. Stern, “Melanosomal alterations in dysplastic melanocytic nevi. A quantitative, ultrastructural investigation,” Cancer, vol. 61, no. 2, pp. 358–369, 1988. View at Google Scholar · View at Scopus
  6. S. Pavel, F. Van Nieuwpoort, H. Van Der Meulen et al., “Disturbed melanin synthesis and chronic oxidative stress in dysplastic naevi,” European Journal of Cancer, vol. 40, no. 9, pp. 1423–1430, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. N. P. M. Smit, F. A. Van Nieuwpoort, L. Marrot et al., “Increased melanogenesis is a risk factor for oxidative DNA damage—study on cultured melanocytes and atypical nevus cells,” Photochemistry and Photobiology, vol. 84, no. 3, pp. 550–555, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. M. R. Hussein and G. S. Wood, “hMLH1 and hMSH2 gene mutations are present in radial growth-phase cutaneous malignant melanoma cell lines and can be induced further by ulraviolet-B irridiation,” Experimental Dermatology, vol. 12, no. 6, pp. 872–875, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. M. R. Hussein, “Genetic pathways to melanoma tumorigenesis,” Journal of Clinical Pathology, vol. 57, no. 8, pp. 797–801, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. R. A. Irizarry, B. Hobbs, F. Collin et al., “Exploration, normalization, and summaries of high density oligonucleotide array probe level data,” Biostatistics, vol. 4, no. 2, pp. 249–264, 2003. View at Google Scholar · View at Scopus
  11. G. W. Wright and R. M. Simon, “A random variance model for detection of differential gene expression in small microarray experiments,” Bioinformatics, vol. 19, no. 18, pp. 2448–2455, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. E. L. Korn, J. F. Troendle, L. M. McShane, and R. Simon, “Controlling the number of false discoveries: application to high-dimensional genomic data,” Journal of Statistical Planning and Inference, vol. 124, no. 2, pp. 379–398, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. L. M. McShane, M. D. Radmacher, B. Freidlin, R. Yu, M. C. Li, and R. Simon, “Methods for assessing reproducibility of clustering pattens observed in analyses of microarray data,” Bioinformatics, vol. 18, no. 11, pp. 1462–1469, 2002. View at Google Scholar · View at Scopus
  14. P. Pavlidis, J. Qin, V. Arango, J. J. Mann, and E. Sibille, “Using the gene ontology for microarray data mining: a comparison of methods and application to age effects in human prefrontal cortex,” Neurochemical Research, vol. 29, no. 6, pp. 1213–1222, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. I. L. A. Boxman, P. J. Hensbergen, R. C. Van Der Schors, D. P. Bruynzeel, C. P. Tensen, and M. Ponec, “Proteomic analysis of skin irritation reveals the induction of HSP27 by sodium lauryl sulphate in human skin,” British Journal of Dermatology, vol. 146, no. 5, pp. 777–785, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Kenmochi, T. Suzuki, T. Uechi et al., “The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders,” Genomics, vol. 77, no. 1-2, pp. 65–70, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. T. W. O'Brien, “Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease,” Gene, vol. 286, no. 1, pp. 73–79, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. A. P. Smith, K. Hoek, and D. Becker, “Whole-genome expression profiling of the melanoma progression pathway reveals marked molecular differences between nevi/melanoma in situ and advanced-stage melanomas,” Cancer Biology and Therapy, vol. 4, no. 9, pp. 1018–1029, 2005. View at Google Scholar · View at Scopus
  19. C. Mischiati, P. G. Natali, A. Sereni et al., “cDNA-array profiling of melanomas and paired melanocyte cultures,” Journal of Cellular Physiology, vol. 207, no. 3, pp. 697–705, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Hoek, D. L. Rimm, K. R. Williams et al., “Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas,” Cancer Research, vol. 64, no. 15, pp. 5270–5282, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Scatolini, M. M. Grand, E. Grosso et al., “Altered molecular pathways in melanocytic lesions,” International Journal of Cancer, vol. 126, no. 8, pp. 1869–1881, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. A. S. Boyd, B. Shakhtour, and Y. Shyr, “Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases,” Journal of the American Academy of Dermatology, vol. 58, no. 5, pp. 750–754, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Alekseenko, A. Wojas-Pelc, G. J. Lis, A. Furgał-Borzych, G. Surówka, and J. A. Litwin, “Cyclin D1 and D3 expression in melanocytic skin lesions,” Archives of Dermatological Research, vol. 302, no. 7, pp. 545–550, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Campoli, J. E. Fitzpatrick, W. High, and S. Ferrone, “HLA antigen expression in melanocytic lesions: is acquisition of HLA antigen expression a biomarker of atypical (dysplastic) melanocytes?” Journal of the American Academy of Dermatology, vol. 66, no. 6, pp. 911–916, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Hodis, I. R. Watson, G. V. Kryukov et al., “A landscape of driver mutations in melanoma,” Cell, vol. 150, no. 2, pp. 251–263, 2012. View at Publisher · View at Google Scholar · View at Scopus