Table 3: Top 16 differentially expressed proteins between melanocytes from dysplastic naevus and from normal skin.

Swiss-prot idProtein nameMol. mass calculated (Da)1 obs.2 calc.3% Pept. Coverage4Ratio 
valueGeneral function

Q9Y2R9Ribosomal protein S72211310.0910430.13100.010946Translational elongation
P32969Ribosomal protein L9219649.969.96290.223340.016167Translational elongation
P78417Glutathione S-transferase omega 1-1278336.236.24210.236270.013815Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities
P62753Ribosomal protein S62884210.910.85230.318900.012139Controlling cell growth and proliferation through the selective translation of particular classes of mRNA
O75947ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d185375.215.21410.321350.027965Mitochondrial membrane ATP synthase that produces ATP from ADP
P04792Heat shock protein 27224277.835.98570.366220.023047Involved in stress resistance and actin organization
P02794Ferritin heavy chain212525.35.08460.400670.006873Stores iron in a soluble, nontoxic, readily available form. Important for iron homeostasis
Q59EQ2Tyrosine 3-monooxy-genase/tryptophan 5-monooxygenase activation protein281794.764.73260.418360.012436Oxidoreductase
P08670Vimentin537105.065.06430.44780.023374Vimentins are class-III intermediate filaments
P07355Annexin A2366318.327.56530.471420.00642May be involved in heat-stress response
P47985Cytochrome b-c1 complex subunit Rieske299348.556.350.477250.008578Component of the ubiquinol-cytochrome c reductase complex
Q5U0F4Eukaryotic translation initiation factor 3368785.385.38323.21550.018194Protein synthesis
O94844GTP-binding Rho-like protein cdc42201235.254.83552.886990.017896The protein may play a role in small GTPase-mediated signal transduction and the organization of the actin filament system
P07237Prolyl 4-hydroxylase574804.764.69462.796510.009987This multifunctional protein catalyzes the formation, breakage, and rearrangement of disulfide bonds
Q6IBR6Platelet-activating factor acetylhydrolase255695.575.572.469630.008975Lipid metabolic process
Q9UBS4DnaJ (Hsp40) homolog, subfamily B407745.815.81302.337370.011076Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains

1Calculated molecular mass of the protein in Dalton (Da).
2Isoelectric point ( ) observed in this study.
3 calculated according to the Mascot database.
4Percentage peptide coverage.
5Protein ratio melanocytes from dysplastic naevus (DNMC)/melanocytes from normal skin (MC).