Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma
Effect of length of UVB treatments on tumor number, tumor burden, and p53 status in male and female mice. (a) Vehicle-treated male and female mice developed more tumors in the 25-week exposure model () compared to the 10-week model. (b) Male () and female () vehicle-treated mice in the 25-week exposure model exhibited increased tumor burden compared to the 10-week model. (c) Male () and female () mice treated with vehicle in the 25-week model exhibited elevated epidermal p53 staining compared to the 10-week exposure model. (d) Male and female mice treated with vehicle in the 25-week exposure model exhibited elevated epidermal mutant p53 staining () compared to the 10-week UVB model. Error bars = mean+/−SEM.