Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma
Efficacy of diclofenac on tumor number, burden, and p53 status in male and female mice. (a) Male and female diclofenac treated mice developed significantly more tumors in the 25- compared to the 10-week model (). (b) Male () and female () diclofenac-treated mice in the 25-week UVB model developed significantly larger tumor burden compared to mice in the 10-week model. (c) Male and female mice treated with diclofenac in the 25-week exposure model did not exhibit significantly altered epidermal p53-positive area compared to the 10-week exposure model. (d) Female mice treated with diclofenac exhibited increased epidermal mutant p53-positive area () in the 25- compared to the 10-week model. Error bars = mean+/−SEM.