Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma
Figure 3
Efficacy of C E Ferulic on tumor number, burden, and p53 status in male and female mice. (a) Male and female mice topically treated with C E Ferulic developed more tumors in the 25- compared to the 10-week model (). (b) Male and female mice topically treated with C E Ferulic developed increased tumor burden in the 25- compared to the 10-week model (). (c) Male mice treated topically with C E Ferulic exhibited increased levels of epidermal p53-positive area in the 25- compared to the 10-week model (). (d) Female mice treated topically with C E Ferulic exhibited increased levels of epidermal mutant p53-positive area in the 25- compared to the 10-week model (). Error bars = mean+/−SEM.
