Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma
Figure 4
Efficacy of vitamin E on tumor number, burden, and p53 status in male and female mice. (a) Male and female mice treated with topical vitamin E developed more tumors in the 25-week compared to the 10-week model (). (b) Male and female mice treated with topical vitamin E exhibited increased tumor burden in the 25- compared to the 10-week model (). (c) Male mice treated with vitamin E exhibited increased epidermal p53-positive area in the 25- compared to the 10-week model (). (d) Female mice treated with vitamin E exhibited significantly increased epidermal mutant p53-positive area in the 25- compared to the 10-week model (). Error bars = mean+/−SEM.
