Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63
Figure 1
Use of alternative splicing gives rise to p63 isoforms of 2 subclasses: TAp63 and Np63. Within each of these subclasses, C-terminal alternative splicing gives rise to , , , , and isoforms. The isoforms share homology in certain protein domains: TA (transactivation domain), N, DBD (DNA binding domain), OD (oligomerization domain), SAM (sterile alpha motif domain), and TID (transactivation inhibition domain).
