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Journal of Skin Cancer
Volume 2014, Article ID 439205, 10 pages
http://dx.doi.org/10.1155/2014/439205
Research Article

Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane

1Laboratory for Molecular Dermatology, Barbara Ann Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
2Department of Dermatology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
3Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA
4Pinkus Dermatopathology Laboratory, Monroe, MI 48162, USA
5Biostatistics, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
6Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
7Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
8Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA

Received 24 January 2014; Revised 2 April 2014; Accepted 15 April 2014; Published 6 May 2014

Academic Editor: Selma Ugurel

Copyright © 2014 Karli Rosner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Karli Rosner, Shreelekha Adsule, Brittany Haynes, Evangelia Kirou, Ikuko Kato, Darius R. Mehregan, and Malathy P.V. Shekhar, “Rad6 is a Potential Early Marker of Melanoma Development,” Translational Oncology, 2014. View at Publisher · View at Google Scholar
  • Hend Kothayer, Sebastian M. Spencer, Kaushlendra Tripathi, Andrew D. Westwell, and Komaraiah Palle, “Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors,” Bioorganic & Medicinal Chemistry Letters, 2016. View at Publisher · View at Google Scholar
  • Ranganatha R. Somasagara, Kaushlendra Tripathi, Sebastian M. Spencer, David W. Clark, Reagan Barnett, Lavanya Bachaboina, Jennifer Scalici, Rodney P. Rocconi, Gary A. Piazza, and Komaraiah Palle, “Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer,” Biochemical And Biophysical Research Communications, vol. 469, no. 3, pp. 449–455, 2016. View at Publisher · View at Google Scholar
  • R R Somasagara, S M Spencer, K Tripathi, D W Clark, C Mani, L Madeira da Silva, J Scalici, H Kothayer, A D Westwell, R P Rocconi, and K Palle, “RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance,” Oncogene, 2017. View at Publisher · View at Google Scholar
  • Francesca Maddalena, Giacomo Lettini, Franca Esposito, and Matteo Landriscina, “RAD6: A new target to overcome platinum resistance in ovarian cancer?,” Translational Cancer Research, vol. 6, pp. S1476–S1479, 2017. View at Publisher · View at Google Scholar
  • Anushka Dikshit, and Jennifer Zhang, “Genetic Mutations and Ubiquitination in Melanoma Growth and Metastasis,” Cancer Metastasis, 2018. View at Publisher · View at Google Scholar