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Journal of Skin Cancer
Volume 2014 (2014), Article ID 793937, 5 pages
http://dx.doi.org/10.1155/2014/793937
Research Article

A Clinicopathological and Immunohistochemical Correlation in Cutaneous Metastases from Internal Malignancies: A Five-Year Study

1Department of Pathology, G.G.S. Medical College & Hospital BFUHS, Faridkot, Punjab 151203, India
2Department of Skin and VD, G.G.S. Medical College & Hospital BFUHS, Faridkot, Punjab 151203, India

Received 16 May 2014; Revised 30 July 2014; Accepted 14 August 2014; Published 25 August 2014

Academic Editor: Günther Hofbauer

Copyright © 2014 Sarita Nibhoria et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cutaneous metastases from internal malignancies are uncommon and occur in 0.6%–10.4% of all patients with cancer. In most cases, cutaneous metastases develop after the initial diagnosis of the primary internal malignancy and late in the course of the disease. Skin tumors are infrequent in Asian population and cutaneous metastases are quite rare. Cutaneous metastases carry a poor prognosis with average survival of few months. In the present five-year study 1924 malignant tumors were screened which included only nine cases of cutaneous metastatic deposits. A wide range of site and clinical presentations including nodules, plaques, and ulcers was noted. Histopathological findings were significant and corresponded with the primary internal malignancy. Cutaneous metastases from breast carcinoma (44.4%) were the most common finding followed by non-Hodgkin lymphoma and renal cell carcinoma (22.2% each) and carcinoma cervix (11.1%). The aim of our study is to classify the cutaneous metastases and to evaluate their clinicopathologic and immunohistochemical correlation with the primary tumor.