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Journal of Skin Cancer
Volume 2015 (2015), Article ID 306543, 6 pages
http://dx.doi.org/10.1155/2015/306543
Research Article

Mycosis Fungoides in Iranian Population: An Epidemiological and Clinicopathological Study

1Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran
2Students’ Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
3Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
4Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
5Students’ Research Committee, Semnan University of Medical Sciences, Semnan, Iran

Received 10 December 2014; Revised 7 January 2015; Accepted 10 January 2015

Academic Editor: Iris Zalaudek

Copyright © 2015 Farahnaz Fatemi Naeini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. Extensive studies on Iranian MF patients are absent. The present study aimed to produce updated clinical information on Iranian MF patients. Methods. This was a retrospective, descriptive, single-center study, including all cases of MF seen in the Department of Dermatology, University Hospital of Isfahan, Iran, between 2003 and 2013. Data systematically recorded for each patient included clinical, biological, histological, and molecular findings. Results. Eighty-six patients with clinical and histologic diagnosis of MF were included in the study. Thirty-nine patients (45.3%) were male. Female predominance was observed in patients (male : female ratio is 1 : 1.2). Patients were between 7 and 84 years of age (median: 41). The interval from disease onset to diagnosis ranged from 0 to 55 years (median: 1 year). Eighteen cases (20.9%) had unusual variants of MF. The most common types included hypopigmented and poikilodermatous MF. Childhood cases of MF constituted 5.8% (5/86) of all patients. The early stages were seen in 82 cases (95.34%). Conclusion. The major differences in epidemiologic characteristics of MF in Iran are the lack of male predominance and the lower age of patients at the time of diagnosis.