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Journal of Skin Cancer
Volume 2015, Article ID 893149, 10 pages
http://dx.doi.org/10.1155/2015/893149
Review Article

Diet and Skin Cancer: The Potential Role of Dietary Antioxidants in Nonmelanoma Skin Cancer Prevention

1Department of Dermatology, Baylor College of Medicine, 1977 Butler Boulevard, Suite E6.200, Houston, TX 77030, USA
2Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA

Received 7 July 2015; Revised 11 September 2015; Accepted 21 September 2015

Academic Editor: Silvia Moretti

Copyright © 2015 Rajani Katta and Danielle Nicole Brown. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nonmelanoma skin cancer (NMSC) is the most common cancer among Americans. Ultraviolet (UV) radiation exposure is the major risk factor for the development of NMSC. Dietary AOs may prevent free radical-mediated DNA damage and tumorigenesis secondary to UV radiation. Numerous laboratory studies have found that certain dietary AOs show significant promise in skin cancer prevention. These results have been substantiated by animal studies. In human studies, researchers have evaluated both oral AO supplements and dietary intake of AOs via whole foods. In this review, we provide an overview of the role of AOs in preventing tumorigenesis and outline four targeted dietary AOs. We review the results of research evaluating oral AOs supplements as compared to dietary AOs intake via whole foods. While these specific supplements have not shown efficacy, intake of AOs via consumption of whole foods has shown some promise. Lessons learned from the field of hypertension research may provide important guidance in future study design. Further research on the role of dietary AOs in the prevention of NMSC is warranted and should focus on intake via whole food consumption.