TY - JOUR A2 - Hofbauer, Günther AU - Hampras, Shalaka S. AU - Reed, Rhianna A. AU - Bezalel, Spencer AU - Cameron, Michael AU - Cherpelis, Basil AU - Fenske, Neil AU - Sondak, Vernon K. AU - Messina, Jane AU - Tommasino, Massimo AU - Gheit, Tarik AU - Rollison, Dana E. PY - 2016 DA - 2016/11/07 TI - Cutaneous Human Papillomavirus Infection and Development of Subsequent Squamous Cell Carcinoma of the Skin SP - 1368103 VL - 2016 AB - The role of cutaneous human papillomavirus (HPV) infection in the development of subsequent cutaneous squamous cell carcinoma (SCC) is unknown. Pathologically confirmed cases of SCC (n=150) enrolled in a previously conducted case-control study were included in a retrospective cohort study to examine the association of cutaneous HPV at the time of SCC diagnosis with the risk of subsequent SCC development. Data on HPV seropositivity, HPV DNA in eyebrow hairs (EB) and SCC tumors were available from the parent study. Incidence of subsequent SCC was estimated using person-years of follow up. Cox Proportional Hazards ratios were estimated to evaluate the associations of both, HPV seropositivity and HPV DNA positivity with subsequent SCC. The five year cumulative incidence of subsequent SCC was 72%. Seropositivity to cutaneous HPV was not associated with the risk of subsequent SCC (HR = 0.83, 95% CI = 0.41–1.67). Any beta HPV infection in EB was associated with reduced risk (HR = 0.30, 95% CI = 0.11–0.78) of subsequent SCC among cases who were positive for beta HPV DNA in tumor tissue. Infection with beta HPV type 2 (HR = 0.32, 95% CI = 0.12–0.86) in EB was associated with reduced risk of subsequent SCC among HPV DNA positive SCCs. In conclusion, beta HPV infection was inversely associated with the risk of subsequent SCC. SN - 2090-2905 UR - https://doi.org/10.1155/2016/1368103 DO - 10.1155/2016/1368103 JF - Journal of Skin Cancer PB - Hindawi Publishing Corporation KW - ER -