Journal of Skin Cancer / 2017 / Article / Tab 1

Review Article

The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma

Table 1

Sensitivity, specificity, positive predictive value, and negative predictive value of BerEP4 in detecting BCC with SCC as control.

StudiesBCC +SCC + (control)

Karahan, et al. [16]20/200/20
Fan, et al. [28]51/51-
Krahl & Sellheyer [29]28/28-
Ishida, et al. [30]20/20-
Filho, et al. [31]20/20-
Mashhood, et al. [32]29/290/11
Tan & Sunjaya [9]23/23-
Kirzhner & Jakobiec [33]13/13-
Dasgeb, et al. [24]24/241/11 (weak positive)
Patil, et al. [12]9/9-
Sellheyer, et al. [34]17/170/75
Ansai, et al. [35]30/31-
BerEP4 positive2841
Ber EP4 negative1116


Sensitivity284/285 × 100 = 99.6%
Specificity116/117 × 100 = 99.2%
Positive predictive value284/285 × 100 = 99.6%
Negative predictive value116/117 × 100 = 99.1%

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