Risk Factors for Developing Nonmelanoma Skin Cancer after Lung Transplantation

Table 5

Cox regression of risk factors for NMSC or precancerous lesions after lung transplantation.

	HR (95% CI)
Variable	Initial Model	P value	Final Model	P value
Male sex	2.69 (1.19 – 6.10)	.02	2.71 (1.24 – 5.94)	.01
Higher age at first lung transplantation, y	1.03 (0.995 – 1.08)	.09	1.03 (0.994 – 1.07)	.10
Fair ski	1.92 (0.69 – 5.26)	.21	2.25 (0.96 – 5.29)	.06
Time of voriconazole exposure,	1.04 (0.9995 – 1.07)	.053	1.03 (1.00 – 1.06)	.04
High UV exposure before LTx	0.998 (0.24 – 4.16)	.998	NA	NA
High UV exposure after LTx	1.01 (0.19 – 5.43)	.99	NA	NA
Minimal sunscreen usage before LTx	0.73 (0.25 – 2.16)	.57	NA	NA
Minimal sunscreen usage after LTX	2.12 (0.61 – 7.33)	.24	NA	NA
Immunosuppression without everolimu	0.93 (0.37 – 2.39)	.89	NA	NA

HR, hazard ratio; CI, confidence interval; UV, ultra violet; LTx, lung transplantation; NA, not applicable.
Representing Fitzpatrick skin types I and II.
Calculated cumulating all periods of voriconazole intake.
Patients not continuously receiving everolimus from LTx to dermatologic examination.