Journal of Skin Cancer

Mouse Models of the Skin: Models to Define Mechanisms of Skin Carcinogenesis


Publishing date
24 May 2013
Status
Published
Submission deadline
04 Jan 2013

1Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 3159 Wisconsin Institutes for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA

2Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 7103 Wisconsin Institutes for Medical Research, 1111 Highland Avenue, Madison, WI 53705, USA

3Department of Pathology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, USA


Mouse Models of the Skin: Models to Define Mechanisms of Skin Carcinogenesis

Description

Skin cancer (basal cell, squamous cell carcinoma, and melanoma) is the most common human cancer, and the multistage model of mouse skin carcinogenesis has been on the forefront for providing clues regarding the cellular, biochemical, and genetic events linked to the initiation, promotion, and progression steps of skin cancer formation. Mouse models of the skin have provided us with unique tools to elucidate the mechanisms of skin carcinogenesis such as identification of both oncogenes and tumor suppressors, the biology of tumor-host cell relationships as well as the role of inflammation in skin cancer. Due to the organized and predictable nature of skin development, mouse models are useful to define the role of stem cells in the development of normal tissues as well as cancer. In the era of molecular targeting and advanced chemotherapeutics, mouse models of the skin provide preclinical models to test and validate new drug combinations as well as elucidating new drug targets to fight cancer.

We invite authors to submit original research and review articles that highlight the use of mouse models of the skin that investigate the multistep nature of skin carcinogenesis, define stem cell biology, skin development, and uses for investigating molecular targeting in cancer. Potential topics include, but are not limited to:

  • Mouse models for multistep carcinogenesis
  • Transgenic and gene knockout mice as models for skin cancer
  • Genetics of skin carcinogenesis
  • Origin of epidermal cancer
  • Modeling human skin cancer in vivo
  • Hair follicle stem cells and skin cancer
  • Modeling melanoma initiation and progression in mouse
  • Modeling human skin cancer in vivo
  • Photocarcinogenesis
  • Cytokines and skin cancer
  • Tumor-host interactions
  • Inflammation and skin cancer

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jsc/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jsc/mmsmdm/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 971495
  • - Editorial

Mouse Models of the Skin: Models to Define Mechanisms of Skin Carcinogenesis

Deric L. Wheeler | Ajit K. Verma | Mitchell F. Denning
  • Special Issue
  • - Volume 2013
  • - Article ID 537028
  • - Review Article

AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer

Richard L. Eckert | Gautam Adhikary | ... | Ellen A. Rorke
  • Special Issue
  • - Volume 2013
  • - Article ID 452425
  • - Research Article

Protein Kinase Cε, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

Ashok Singh | Anupama Singh | ... | Ajit K. Verma
  • Special Issue
  • - Volume 2013
  • - Article ID 632028
  • - Review Article

Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63

Kathryn E. King | Linan Ha | ... | Wendy C. Weinberg
  • Special Issue
  • - Volume 2013
  • - Article ID 684050
  • - Review Article

Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models

Everardo Macias | Dharanija Rao | John DiGiovanni
  • Special Issue
  • - Volume 2012
  • - Article ID 249063
  • - Review Article

The Role of TGF Signaling in Squamous Cell Cancer: Lessons from Mouse Models

Adam B. Glick
  • Special Issue
  • - Volume 2012
  • - Article ID 147863
  • - Research Article

Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model

Kunal Sonavane | Jeffrey Phillips | ... | Cherie-Ann O. Nathan
  • Special Issue
  • - Volume 2012
  • - Article ID 483439
  • - Review Article

Multiple Roles for VEGF in Non-Melanoma Skin Cancer: Angiogenesis and Beyond

Kelly E. Johnson | Traci A. Wilgus
  • Special Issue
  • - Volume 2012
  • - Article ID 907543
  • - Review Article

Patched Knockout Mouse Models of Basal Cell Carcinoma

Frauke Nitzki | Marco Becker | ... | Heidi Hahn
Journal of Skin Cancer
 Journal metrics
Acceptance rate29%
Submission to final decision34 days
Acceptance to publication25 days
CiteScore2.100
Impact Factor-
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