Interactions of Gut Microbiota, Endotoxemia, Immune Function, and Diet in Exertional Heatstroke
The relative abundance (%) of bacterial processes in the IM of 10 healthy adults (labelled A–O, Panel A, -axis). Sequence data from 10 individuals was searched against a database (gCOGdb) of completely sequenced bacterial genomes (= 1,012; National Center for Biotechnology Information, 2009) and assigned to Clusters of Orthologous Groups (COG) categories, which indicate likely protein function. Data suggest that carbohydrate and lipid metabolism, energy production, and synthesis of cellular components are the main functions of gut microbiota in these individuals. The rate ratio value (Panel B) was calculated to measure whether COG patterns observed in the 10 individuals were likely due to biases in the existing reference database (gCOGdb). Rate ratios ≠ 1.0 indicate that some categories are over- or underrepresented in the sample of 10 individuals compared to the gCOGdb; these processes likely represent real differences in processes among the 10 individual IM evaluated, above and beyond artifact that might be present in the distribution of COG categories in the general gCOGdb. Reprinted from Gosalbes et al. .
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