Table of Contents
Journal of Soft Matter
Volume 2014 (2014), Article ID 863096, 9 pages
http://dx.doi.org/10.1155/2014/863096
Research Article

Preparation and Properties of 3D Chitosan Microtubes

1Educational and Research Institute Nanostructures and Biosystems, Saratov State University, 83 Ulitsa Astrakhanskaya, Saratov 410012, Russia
2Institute of Chemistry, Saratov State University, 83 Ulitsa Astrakhanskaya, Saratov 410012, Russia

Received 24 April 2014; Revised 15 July 2014; Accepted 17 July 2014; Published 12 August 2014

Academic Editor: Jie Han

Copyright © 2014 Natalia O. Gegel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The preparation of 3D chitosan microtubes from polymer solutions in citric and lactic acids by the wet and dry molding methods is described. The mechanism of formation of the insoluble polymeric layer constructing the walls of these microtubes is characterized. The microtubes obtained from chitosan solutions in citric acid are found to have a fragile porous inner layer. For those obtained from chitosan solutions in lactic acid the morphology, elastic-deformation properties, physicomechanical properties, and biocompatibility were assessed. These samples have smooth outer and inner surfaces with no visible defects and high values of elongation at break. The strength of the microtubes obtained by the dry method is much higher than in the case of the wet one. A high adhesion and high proliferative activity of the epithelial-like MA-104 cellular culture on the surface of our microtubular substrates in model in vitro experiments were revealed. Prospects of using chitosan microtubes as vascular prostheses are suggested.