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Volume 16 (2002), Issue 3-4, Pages 251-255

Temperature Induced Conformational Transitions of Elastin-Like Polypentapeptides Studied by Raman and NMR Spectroscopy

Jirí Dybal,1 Pavel Schmidt,1 Dana Kurková,1 Jaroslav Kríž,1 José Carlos Rodríguez-Cabello,2 and Matilde Alonso3

1Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague 6, Czech Republic
2Department of Condensed Matter, E.T.S.I.I., University of Valladolid, 47011 Valladolid, Spain
3Department of Analytical Chemistry, E.U.P., University of Valladolid, 47014 Valladolid, Spain

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Raman and NMR spectroscopy together with DFT quantum chemical calculations have been used to elucidate conformational changes occurring during inverse temperature transition in water solution of two elastin-like polypentapeptides, poly(G1V1G2V2P) and poly(AV1GV2P). From the temperature dependences of Raman spectra and 1H–1H NOESY spectra follows that above the transition temperature a β(II)-turn conformational structure is formed on the residue located between Pro and Val1.