Naoko Fujioka, Yuji Morimoto, Tsunenori Arai, Kyoko Takeuchi, Masahiko Yoshioka, Makoto Kikuchi, "Differences between infrared spectra of normal and neoplastic human gastric cells", Journal of Spectroscopy, vol. 18, Article ID 347480, 8 pages, 2004. https://doi.org/10.1155/2004/347480
Differences between infrared spectra of normal and neoplastic human gastric cells
We investigated the differences in Fourier transform‒infrared (FT‒IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU‒1, and NCI‒N87) showed a significant increase in infrared absorption in the band around 1240 cm¯1, 1120 cm¯1 and 1080 cm¯1, compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm¯1 and 3.8 cm¯1 were seen at the peak absorbance in the bands around 1240 cm¯1 and 1080 cm¯1, respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT‒IR spectroscopy is a potential new tool for gastric cancer diagnosis.
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