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Spectroscopy
Volume 18, Issue 1, Pages 59-66
http://dx.doi.org/10.1155/2004/347480

Differences between infrared spectra of normal and neoplastic human gastric cells

Naoko Fujioka,1 Yuji Morimoto,1 Tsunenori Arai,2 Kyoko Takeuchi,3 Masahiko Yoshioka,3 and Makoto Kikuchi1

1Department of Medical Engineering, National Defense Medical College, 3‒2 Namiki, Tokorozawa, Saitama 359‒8513, Japan
2Department of Applied Physics and Physico‒Informatics, the Faculty of Science and Technology, Keio University, 3‒14‒1 Hiyoshi, Kohoku‒ku, Yokohama, Kanagawa 223‒8522, Japan
3First Department of Anatomy, National Defense Medical College, 3‒2 Namiki, Tokorozawa, Saitama 359‒8513, Japan

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated the differences in Fourier transform‒infrared (FT‒IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU‒1, and NCI‒N87) showed a significant increase in infrared absorption in the band around 1240 cm¯1, 1120 cm¯1 and 1080 cm¯1, compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm¯1 and 3.8 cm¯1 were seen at the peak absorbance in the bands around 1240 cm¯1 and 1080 cm¯1, respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT‒IR spectroscopy is a potential new tool for gastric cancer diagnosis.