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Volume 18, Issue 2, Pages 133-142

1H MRS phantom studies of BNCT 10B‒carrier, BPA–F using STEAM and PRESS MRS sequences: Detection limit and quantification

M. Timonen,1,2 A. Kangasmäki,1,3 S. Savolainen,1,2,3 and S. Heikkinen1,4

1Department of Radiology, Helsinki University Central Hospital, P.O. Box 340, FIN‒00029 HUS, Helsinki, Finland
2Department Physical Sciences, University of Helsinki, P.O. Box 64, FIN‒00014, Helsinki, Finland
3Department of Laboratory Diagnostics, Helsinki University Central Hospital, P.O. Box 580, FIN‒00029 HUS, Helsinki, Finland
4Advanced Magnetic Imaging Centre, Helsinki University of Technology, FIN‒02015 HUT, Espoo, Finland

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The quantification of boron neutron capture therapy (BNCT) 10B‒carrier, L‒p‒boronophenylalanine‒fructose complex (BPA–F) was studied with phantoms using 1H magnetic resonance spectroscopy sequences PRESS and STEAM at 1.5 and 3.0 T. The results show that typical attainable short echo times of clinical MRS sequences combined with long repetition time result in clinically acceptable quantification accuracy. However, the concentration ratios, which are essential for the treatment planning, can still be reliably measured by using small repetition times. Detection limits of BPA in aqueous phantoms at 1.5 and 3.0 T were evaluated using clinically acceptable measurement time of ~10 min, two typical voxel sizes (153 and 203 mm3) and PRESS and STEAM sequences. The detection limits of BPA in phantom conditions were 0.7 (3.0 T) and 1.4 mM (1.5 T) for PRESS sequence with 203 mm3 voxel.