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Spectroscopy
Volume 20 (2006), Issue 3, Pages 109-123
http://dx.doi.org/10.1155/2006/314052

Applications of NMR spectroscopy in understanding the gold biochemistry

Anvarhusein A. Isab1 and Saeed Ahmad2

1Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia
2Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gold-based drugs have been successfully used for the treatment of rheumatoid arthritis. When administered, they undergo ligand exchange reactions in the body with biofluids, cells and proteins. NMR spectroscopy is a very useful technique for probing these ligand exchange reactions under physiological conditions. The strength of the binding ligands can be estimated by studying the chemical shift changes in 13C and 31P NMR. It is also a powerful method for investigating the kinetics and thermodynamics of the exchange reactions of gold drugs with biomolecules. The purpose of this review report is to highlight the importance of NMR spectroscopy in the study of gold biochemistry and to bridge the fairly large gap in the progress of this interesting area of bioinorganic chemistry.