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Volume 21, Issue 5-6, Pages 257-268

The structural stability of protein antigens adsorbed by aluminium hydroxide in comparison to the antigens in solutions

Yiwu Zheng,1,2 Xuxin Lai,1,2 Henrik Ipsen,1 Jørgen Nedergaard Larsen,1 Henning Løwenstein,1 Ib Søndergaard,2 and Susanne Jacobsen2

1ALK-ABELLO A/S, Hørsholm, Denmark
2Enzyme and Protein Chemistry, BioCentrum-DTU, Technical University of Denmark, Kgs. Lyngby, Denmark

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [5 citations]

The following is the list of published articles that have cited the current article.

  • Tanya Clapp, Paul Siebert, Dexiang Chen, and LaToya Jones Braun, “Vaccines with aluminum-containing adjuvants: Optimizing vaccine efficacy and thermal stability,” Journal of Pharmaceutical Sciences, vol. 100, no. 2, pp. 388–401, 2011. View at Publisher · View at Google Scholar
  • Mildred Ugozzoli, Donatello Laera, Sandra Nuti, David A.G. Skibinski, Simone Bufali, Chiara Sammicheli, Simona Tavarini, Manmohan Singh, and Derek T. O'Hagan, “Flow cytometry: An alternative method for direct quantification of antigens adsorbed to aluminum hydroxide adjuvant,” Analytical Biochemistry, vol. 418, no. 2, pp. 224–230, 2011. View at Publisher · View at Google Scholar
  • Marie Régnier, Bernard Metz, Wichard Tilstra, Coenraad Hendriksen, Wim Jiskoot, Willem Norde, and Gideon Kersten, “Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant,” Vaccine, vol. 30, no. 48, pp. 6783–6788, 2012. View at Publisher · View at Google Scholar
  • Padma Malyala, Donatello Laera, Simona Cianetti, Simone Bufali, Marianna Aggravi, Elvira Ianni, Casey Judge, Gillis Otten, Manmohan Singh, and Derek T. O' Hagan, “The Preparation and Physicochemical Characterization of Aluminum Hydroxide/TLR7a, a Novel Vaccine Adjuvant Comprising a Small Molecule Adsorbed to Aluminum Hydroxide,” Journal of Pharmaceutical Sciences, 2018. View at Publisher · View at Google Scholar
  • Kristen Kalbfleisch, Sasmit Deshmukh, Carmen Mei, Moriam Ore, Wayne Williams, Ibrahim Durowoju, Jessica Duprez, Sylvie Morin, Bruce Carpick, and Marina Kirkitadze, “Identity, structure and compositional analysis of aluminum phosphate adsorbed pediatric quadrivalent and pentavalent vaccines,” Computational and Structural Biotechnology Journal, 2018. View at Publisher · View at Google Scholar