I. Bratu, Irina Kacso, Gh. Borodi, Daniela E. Constantinescu, Felicia Dragan, "Inclusion compound of Fosinopril with β-cyclodextrin", Journal of Spectroscopy, vol. 23, Article ID 275398, 8 pages, 2009. https://doi.org/10.3233/SPE-2009-0373
Inclusion compound of Fosinopril with β-cyclodextrin
Solid state interactions of bioactive substance (4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxy-propoxy)-(4-phenylbutyl)phosphoryl]acetyl]-pyrrolidine-2-carboxylic acid, called Fosinopril), with β-cyclodextrin (β-CD), the so-called inclusion compounds of a bioactive (cardiovascular) drug is obtained by different preparation methods: kneading, co-precipitation and freeze-drying. The so obtained compounds were investigated by FTIR spectroscopy, X-ray diffraction method, and differential scanning calorimetric measurements (DSC) to evidence their formation. X-ray diffraction patterns show that the inclusion compound was obtained for kneaded, co-precipitation and freeze-dried products. The crystalline/amorphous degree for these compounds was also investigated. Molecular modeling (MM+ molecular mechanics) shows the spatial architecture of the inclusion compound in good agreement with FTIR experimental data: the drug is included with the propanoyloxy-propoxy group inside β-cyclodextrin cavity. These findings may constitute a direct contribution to the molecular encapsulation of Fosinopril into β-cyclodextrin, improving Fosinopril stability and bioavailability of the drug, also.
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