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Spectroscopic studies of the inclusion compound of lisinopril withβ-cyclodextrin
Alexandra Olaru,1 Gh. Borodi,2 Iren Kacsó,2 M. Vasilescu,1 I. Bratu
,2,3 and O. Cozar11Faculty of Physics, “Babes-Bolyai” University, Cluj-Napoca, Romania
2Physics of Multifunctional Nanostructured Systems Department, National Institute for R&D of Isotopic and Molecular Technologies, Cluj-Napoca, Romania
3Physics of Multifunctional Nanostructured Systems Department, National Institute for R&D of Isotopic and Molecular Technologies, Cluj-Napoca, P.O. Box 700, R-400293 Cluj-Napoca, Romania
Abstract
The inclusion compounds of lisinopril with β-cyclodextrin, prepared by different methods: kneading, co-precipitation and freeze-drying were investigated by XRD, FTIR, DSC and solid-state NMR techniques. It was established by these methods that the complexation process was successfully. The degree of crystallinity for the product obtained by kneading was also determined. The kneaded product has a certain crystallinity degree, so it is possible that the inclusion process is less effective in this case. In the case of freeze-dried and co-precipitated products only amorphous phase exists, i.e. the complexation was produced with a higher efficiency.
Copyright
Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
