Journal of Spectroscopy

Journal of Spectroscopy / 2009 / Article

Open Access

Volume 23 |Article ID 837158 | https://doi.org/10.3233/SPE-2009-0386

Alexandra Olaru, Gh. Borodi, Iren Kacsó, M. Vasilescu, I. Bratu, O. Cozar, "Spectroscopic studies of the inclusion compound of lisinopril withβ-cyclodextrin", Journal of Spectroscopy, vol. 23, Article ID 837158, 9 pages, 2009. https://doi.org/10.3233/SPE-2009-0386

Spectroscopic studies of the inclusion compound of lisinopril withβ-cyclodextrin

Abstract

The inclusion compounds of lisinopril with β-cyclodextrin, prepared by different methods: kneading, co-precipitation and freeze-drying were investigated by XRD, FTIR, DSC and solid-state NMR techniques. It was established by these methods that the complexation process was successfully. The degree of crystallinity for the product obtained by kneading was also determined. The kneaded product has a certain crystallinity degree, so it is possible that the inclusion process is less effective in this case. In the case of freeze-dried and co-precipitated products only amorphous phase exists, i.e. the complexation was produced with a higher efficiency.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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