Journal of Spectroscopy

Journal of Spectroscopy / 2010 / Article
Special Issue

From Molecule to Tissue: XIII European Conference on the Spectroscopy of Biological Molecules, Palermo, Italy, August 28–September 2, 2009, Part 2 of 2

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Open Access

Volume 24 |Article ID 259258 | https://doi.org/10.3233/SPE-2010-0449

S. Khrapunov, H. Cheng, S. Hegde, J. Blanchard, M. Brenowitz, "Unusual structural characteristics of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA", Journal of Spectroscopy, vol. 24, Article ID 259258, 3 pages, 2010. https://doi.org/10.3233/SPE-2010-0449

Unusual structural characteristics of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA

Abstract

The solution structure and refolding of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA was explored by fluorescence and circular dichroism spectroscopy. Our results show that MfpA exists in two stable structural forms which exclusively favor dimer or oligomer formation. The structural malleability of MfpA may provide a novel target for drug discovery.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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