Journal of Spectroscopy

Journal of Spectroscopy / 2010 / Article
Special Issue

From Molecule to Tissue: XIII European Conference on the Spectroscopy of Biological Molecules, Palermo, Italy, August 28–September 2, 2009, Part 1 of 2

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Volume 24 |Article ID 273028 | https://doi.org/10.3233/SPE-2010-0426

Claire S. Sweetenham, Ioan Notingher, "Raman spectroscopy methods for detecting and imaging supported lipid bilayers", Journal of Spectroscopy, vol. 24, Article ID 273028, 5 pages, 2010. https://doi.org/10.3233/SPE-2010-0426

Raman spectroscopy methods for detecting and imaging supported lipid bilayers

Abstract

We have developed a Raman microspectroscopy system optimised for studying supported lipid bilayers (SLB). This system combines the benefits of Raman spectroscopy with the high spatial resolution of confocal microscopy. Furthermore, the additional incorporation of an atomic force microscope (AFM) makes it possible to directly correlate chemical information with spatial features of samples at the nanoscale. We focus on the limits of this system for detecting a single SLB and imaging its microdomains, and employ surface-enhanced Raman spectroscopy (SERS) to improve the sensitivity achieved with Raman microspectroscopy.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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