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Spectroscopy
Volume 26, Issue 2, Pages 115-128
http://dx.doi.org/10.3233/SPE-2011-0519

Spectroscopic and physical–chemical characterization of ambazone–glutamate salt

Marieta Muresan-Pop,1 Irina Kacsó,2 Xenia Filip,2 Emilia Vanea,1 G. Borodi,2 N. Leopold,1 I. Bratu,2,3 and S. Simon1

1Babeş-Bolyai University, Faculty of Physics, Cluj-Napoca, Romania
2National Institute for R&D of Isotopic and Molecular Technologies, Cluj-Napoca, Romania
3National Institute for R&D of Isotopic and Molecular Technologies, 400293 Cluj-Napoca, Romania

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ambazone monohydrate C8H11N7S · H2O (AMB), a well-known antimicrobial compound, was used together with Glutamic Acid C5H9NO4 (Glu) to obtain a new solid form using the solvent-drop grinding procedure. The screening of the new solid form was best achieved by the combined use of X-ray Powder Diffraction (XRPD) and several spectroscopic techniques (Fourier Transformed Infrared Spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS), Raman and 13C-NMR spectroscopy) together with Differential Scanning Calorimetry (DSC), Differential thermal analysis and thermogravimetry (DTA–TGA). The combination of the mentioned analytical techniques allows the compound to be assigned to an ambazone–glutamate salt which crystallizes in monoclinic system having the following lattice parameters: a=9.8352, b=4.7014, c=40.0987 Å and β=94.505°. DSC, TGA data and the before mentioned spectroscopic techniques support the ambazone–glutamate salt formation.