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Spectroscopy: An International Journal
Volume 27 (2012), Article ID 136058, 6 pages

Spectroscopic Studies of Methimazole Reactivity toward the Aquapentacyanoferrate (II) Ion in Aqueous Solutions

Department of Chemistry and Biochemistry, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia

Copyright © 2012 D. Cvijanović et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Methimazole (2-mercapto-1-methylimidazole, MMI) and its pentacyanoferrate (II) complex have been characterized by means of UV/Vis, Raman, and NMR spectroscopy. The reaction of MMI with aquapentacyanoferrate (II), [Fe(CN)5(H2O)]3−, in buffered aqueous solutions yielded the [Fe(CN)5(MMI)]3− complex. It was found that only thione tautomer of MMI coordinates to the iron (II). The exceptionally stabile and inert complex was produced.