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Volume 27, Issue 1, Pages 49-58

Structural characterization of ambazone salt with niflumic acid

Irina Kacso,1 Lucia Rus,2 Mircea Pop,1 Gheorghe Borodi,1 and Ioan Bratu1,3

1National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania
2Department of Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy, Cluj-Napoca, Romania
3National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donáth street, 400293 Cluj-Napoca, Romania

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Salt formation is a good method of increasing solubility, dissolution rate and consequently the bioavailability of poor soluble acidic or basic drugs [Polymorphism in Pharmaceutical Solids, Drugs and the Pharmaceutical Sciences, Vol. 192, 2nd edn, Informa Healthcare, New York, 2009]. The aim of this study was to obtain and to investigate the structural properties of the compound obtained by solvent drop grinding (SDG) method [Chem. Commun. (Camb.) 20 (2002), 2372–2373] at room temperature starting from the 1:1 molar ratios of ambazone (AMB) and niflumic acid (NIA). The thermal behavior of the obtained compound (AMB · NIA) was investigated by differential scanning calorimetry (DSC) and thermogravimetry (TG), the thermal diffusivity and effusivity parameters were determined by photothermal radiometry (PTR). The structural characterization was performed with X-ray powder diffraction (XRPD) and infrared spectroscopy (FTIR). XRPD data and FTIR spectra demonstrated a new structure for AMB · NIA compound as compared to those of the starting materials.