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Journal of Spectroscopy
Volume 2013 (2013), Article ID 146541, 7 pages
http://dx.doi.org/10.1155/2013/146541
Research Article

Complete Assignment of 𝟏 H and 𝟏 𝟑 C NMR Spectra of 1,2,4-Trisubstituted Pyrroles

1Equipe “Recherche et Innovation en Chimie Médicinale”, Laboratoire d’Infectiologie et Santé Publique (UMR UFR/INRA 1282), Faculté des Sciences et Techniques, Université François Rabelais, Parc de Grandmont, 37200 Tours, France
2Groupe S.U.C.R.E.S-UMR 7565, Nancy Université-CNRS, BP 70239, 54506 Nancy Vandoeuvre, France

Received 22 June 2012; Revised 25 July 2012; Accepted 25 July 2012

Academic Editor: Christophe Dujardin

Copyright © 2013 Elsa Anselmi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

1,2,4-Trisubstituted pyrroles were synthesized with an original one-pot domino allylic amination/palladium-catalysed Sonogashira cross-coupling and heterocyclisation process. 1H and 13C NMR spectra were assigned for twelve new compounds containing different substituents in positions 1 and 2, and a carboxylic acid or ester group in position 4. Each assignment was based on the combination of one, and two-dimensional experiments (APT, COSY, HMBC).