New Spectrophotometric and Conductometric Methods for Macrolide Antibiotics Determination in Pure and Pharmaceutical Dosage Forms Using Rose Bengal

Table 2

Determination of erythromycin thiocyanate and clarithromycin in their pharmaceutical dosage forms through complexation with Cu(II) chloride and rose bengal by spectrophotometric procedure*.

Erythrocin tablets				Erythrocin Pharco suspension				Klarimix tablets				Klarimix suspension
Claimed to be taken 𝜇g/mL	Authentic added 𝜇g/mL	Found conc. 𝜇g/mL	Recovery %	Claimed to be taken 𝜇g/mL	Authentic added 𝜇g/mL	Found conc. 𝜇g/mL	Recovery %	Claimed to be taken 𝜇g/mL	Authentic added 𝜇g/mL	Found conc. 𝜇g/mL	Recovery %	Claimed to be taken 𝜇g/mL	Authentic added 𝜇g/mL	Found conc. 𝜇g/mL	Recovery %
15		14.99	99.93	15		14.94	99.59	7.5		7.56	100.80	10		10.05	100.48
	15	14.89	99.24		15	15.04	100.28		7.5	7.46	99.52		10	10.14	101.44
	20	19.86	99.30		20	20.02	100.08		10	10.10	100.96		12.5	12.39	99.14
	22.5	22.50	100.01		25	25.04	100.17		15	15.12	100.80		15	14.98	99.84
	25	25.20	100.79		30	29.91	99.71		17.5	17.27	98.70		17.5	17.46	99.79
	27.5	27.74	100.86		32.5	32.61	100.33		20	20.14	100.72		20	20.05	100.24
	30	29.76	99.19		35	34.83	99.53		22.5	22.44	99.73		22.5	22.68	100.80
	35	35.15	100.41		40	40.12	100.30		25	25.17	100.67		27.5	27.56	100.22
	37.5	37.58	100.21		42.5	42.55	100.13		27.5	27.56	100.22		30	30.05	100.16
	40	39.65	99.19						30	29.95	99.84
Mean			99.91				100.01				100.20				100.23
Variance			0.44				0.10				0.54				0.42
SD			0.66				0.32				0.73				0.65
SE			0.15				0.11				0.24				0.23

*Average of three experiments.