New Spectrophotometric and Conductometric Methods for Macrolide Antibiotics Determination in Pure and Pharmaceutical Dosage Forms Using Rose Bengal

Table 3

Determination of azithromycin dihydrate in its pharmaceutical dosage forms through complexation with Cu(II) chloride and rose bengal by spectrophotometric procedure*.

Azrolid tablets				Zithrokan capsules				Zithrokan suspension
Claimed to be taken 𝜇g/mL	Authentic added 𝜇g/mL	Found conc. 𝜇g/mL	Recovery %	Claimed to be taken 𝜇g/mL	Authentic added 𝜇g/mL	Found conc. 𝜇g/mL	Recovery %	Claimed to be taken 𝜇g/mL	Authentic added 𝜇g/mL	Found conc. 𝜇g/mL	Recovery %
4		4.03	100.77	4		4.01	100.36	4		4.05	101.18
	4	4.01	100.36		4	4.08	101.99		4	4.05	101.18
	7	7.01	100.19		5	4.97	99.42		6	6.06	100.95
	8	8.00	100.02		6	6.02	100.41		8	8.02	100.22
	9	8.96	99.53		8	7.97	99.62		10	10.06	100.60
	10	10.03	100.28		9	9.06	100.61		12	11.99	99.91
	11	11.11	101.03		10	10.00	99.95		14	14.01	100.10
	12	11.97	99.77		11	10.98	99.85		16	15.89	99.34
	14	14.03	100.22		12	12.02	100.18
	16	15.89	99.34		13	12.99	99.95
Mean			100.15				100.23				100.43
Variance			0.27				0.51				0.43
SD			0.52				0.72				0.66
SE			0.17				0.24				0.25

*Average of three experiments.