New Spectrophotometric and Conductometric Methods for Macrolide Antibiotics Determination in Pure and Pharmaceutical Dosage Forms Using Rose Bengal

Table 7

Determination of the studied drugs by the proposed spectrophotometric and conductmetric methods compared with the reported method [6].

	(I)	(II)	(III)
Spectrophotometric method
Mean ± R.S.D.	100.05±0.54	100.01±0.47	99.87±0.50
Variance	0.29	0.22	0.25
Student’s 𝑡-test	0.05 (2.17)*	0.4 (1.31)*	0.06 (2.16)*
𝐹-test	2.38 (4.28)*	3.91 (3.60)*	2.68 (3.89)*
𝑛	7	9	9
Conductometric method
Mean ± R.S.D.	100.66±0.93	100.65±0.63	100.62±0.62
Variance	0.87	0.40	0.38
Student’s 𝑡-test	1.31 (2.17)*	1.13 (2.17)*	2.10 (2.228)*
𝐹-test	1.26 (3.87)*	2.15 (3.97)*	1.76 (8.05)*
𝑛	7	6	6
Reported method [6]
Mean ± R.S.D.	100.04±0.83	100.15 ± 0.93	99.89 ± 0.82
Variance	0.69	0.86	0.67
Student’s 𝑡-test	—	—	—
𝐹-test	—	—	—
𝑛	7	8	6

*The figures in parenthesis are the theoretical values for 𝑡 and 𝐹-tests (𝑃<0.05).