Table of Contents Author Guidelines Submit a Manuscript
Journal of Spectroscopy
Volume 2013, Article ID 593636, 6 pages
http://dx.doi.org/10.1155/2013/593636
Research Article

Preparation and Characterization of Lanthanum Carbonate Octahydrate for the Treatment of Hyperphosphatemia

1College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
2School of Materials Science and Technology, China University of Geosciences, Beijing 100083, China
3Beijing Coway Pharm. Co. Ltd., Beijing 100094, China
4School of Medicine, Henan University, Kaifeng 471003, China
5Tianjin Cenway Pharm. Co. Ltd., Tianjin 300480, China
6College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Shenyang 11660, China
7College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, China

Received 6 September 2013; Accepted 15 October 2013

Academic Editor: Isao Noda

Copyright © 2013 Anqi He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We proposed a new approach to prepare lanthanum carbonate via reactions between lanthanum chloride and NaHCO3. In the reaction, small amount of NaHCO3 solution was firstly added to the acidic lanthanum chloride solution to generate lanthanum carbonate nuclei and then NaHCO3 is added to the lanthanum chloride at a constant speed. This approach makes both precipitation reaction and neutralization reaction take place simultaneously. Consequently, lanthanum carbonate is produced at low pH environment (pH below 4.0) so that the risk of generating lanthanum carbonate hydroxide is reduced. The product of the above reaction is validated by EDTA titration, elemental analysis, and XRD characterization. In addition, we established a FTIR spectroscopic method to identify La(OH)CO3 from La2(CO3)2·8H2O. Lanthanum carbonate exhibits considerable ability to bind phosphate.