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Journal of Spectroscopy
Volume 2014, Article ID 213890, 4 pages
http://dx.doi.org/10.1155/2014/213890
Research Article

The Use of FTIR-ATR Spectrometry for Evaluation of Surgical Resection Margin in Colorectal Cancer: A Pilot Study of 56 Samples

1Department of General Surgery, Peking University Third Hospital, Beijing 100191, China
2Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Beijing 100191, China
3College of Chemistry and Molecular Engineering, State Key Laboratory of Rare Earth Material Chemistry and Application, Peking University, Beijing 100871, China

Received 6 September 2013; Revised 11 November 2013; Accepted 14 December 2013; Published 16 January 2014

Academic Editor: Yizhuang Xu

Copyright © 2014 Hongwei Yao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Colorectal cancer is one of the most common malignancies in human, and it is also one of the most leading causes of cancer-related death. Recently, Fourier transform infrared (FTIR) spectrometry is considered to develop into a new method for cancer diagnosis. In this study, colorectal cancer and mucosa 1 cm, 2 cm, and 5 cm away from tumor were measured by FTIR spectroscopy. FTIR spectra of colorectal cancer and mucosa 1 cm away from tumor were different from those of mucosa 2 cm and 5 cm away from tumor. According to the analysis of FTIR spectrometry, the decrease of lipid and the increase of protein and nucleic acid were observed in the former two sites. FTIR spectrometry, therefore, may be developed into a rapid promising method for judging surgical resection margin of colorectal cancer.