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Journal of Spectroscopy
Volume 2016, Article ID 1947613, 23 pages
http://dx.doi.org/10.1155/2016/1947613
Review Article

Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging

1Department of Electrical and Computer Engineering, Université de Sherbrooke, 2500 Boulevard de l’Université, Sherbrooke, QC, Canada J1K 2R1
2Centre d’Imagerie Moléculaire de Sherbrooke (CIMS), Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CR-CHUS), 3001 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4
3Institut Interdisciplinaire d’Innovation Technologique (3IT), Parc Innovation, Pavillon P2, 3000 Boulevard de l’Université, Sherbrooke, QC, Canada J1K 0A5
4Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy

Received 2 October 2015; Revised 5 December 2015; Accepted 20 December 2015

Academic Editor: Rickson C. Mesquita

Copyright © 2016 Yves Bérubé-Lauzière et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Wang and H. Wu, Biomedical Optics—Principles and Imaging, Wiley-Interscience, 2007.
  2. A. D. Klose, “Radiative transfer of luminescence light in biological tissue,” in Light Scattering Reviews 4, Springer Praxis Books, chapter 6, pp. 293–345, Springer, Berlin, Germany, 2009. View at Publisher · View at Google Scholar
  3. American National Standard for Safe Use of Lasers—ANSI Z136.1-2014, Laser Institute of America (LIA) and American National Standards Institute (ANSI), 2014.
  4. Safety of Laser Products Part 1: Equipment Classification and Requirements—IEC 60825-1:2014, Edition 3, International Electrotechnical Commission, Geneva, Switzerland, 2014.
  5. S. Prahl and S. Jacques, Optical Properties Spectra, 2015, http://omlc.org/spectra/index.html.
  6. R. B. Buxton, Introduction to Functional Magnetic Resonance Imaging: Principles and Techniques, Cambridge University Press, Cambridge, UK, 2009. View at Publisher · View at Google Scholar
  7. E. Ranyuk, R. Lebel, Y. Bérubé-Lauzière et al., “68Ga/DOTA- and 64Cu/NOTA-phthalocyanine conjugates as fluorescent/PET bimodal imaging probes,” Bioconjugate Chemistry, vol. 24, no. 9, pp. 1624–1633, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. M. L. James and S. S. Gambhir, “A molecular imaging primer: modalities, imaging agents, and applications,” Physiological Reviews, vol. 92, no. 2, pp. 897–965, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Wang, S. Jiang, Z. Li et al., “In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography,” Medical Physics, vol. 37, no. 7, pp. 3715–3724, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. Q. Fang, J. Selb, S. A. Carp et al., “Combined optical and x-ray tomosynthesis breast imaging,” Radiology, vol. 258, no. 1, pp. 89–97, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. M. L. Flexman, H. K. Kim, J. E. Gunther et al., “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” Journal of Biomedical Optics, vol. 18, no. 9, Article ID 096012, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Choe, S. D. Konecky, A. Corlu et al., “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” Journal of Biomedical Optics, vol. 14, no. 2, Article ID 024020, 2009. View at Publisher · View at Google Scholar
  13. L. D. Montejo, J. Jia, H. K. Kim et al., “Computer-aided diagnosis of rheumatoid arthritis with optical tomography, part 2: image classification,” Journal of Biomedical Optics, vol. 18, no. 7, Article ID 076002, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Piao, K. E. Bartels, Z. Jiang et al., “Alternative transrectal prostate imaging: a diffuse optical tomography method,” IEEE Journal on Selected Topics in Quantum Electronics, vol. 16, no. 4, pp. 715–729, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. K. K.-H. Wang and T. C. Zhu, “Reconstruction of in-vivo optical properties for human prostate using interstitial diffuse optical tomography,” Optics Express, vol. 17, no. 14, pp. 11665–11672, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. A. P. Gibson, T. Austin, N. L. Everdell et al., “Three-dimensional whole-head optical tomography of passive motor evoked responses in the neonate,” NeuroImage, vol. 30, no. 2, pp. 521–528, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. D. K. Joseph, T. J. Huppert, M. A. Franceschini, and D. A. Boas, “Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging,” Applied Optics, vol. 45, no. 31, pp. 8142–8151, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. A. T. Eggebrecht, S. L. Ferradal, A. Robichaux-Viehoever et al., “Mapping distributed brain function and networks with diffuse optical tomography,” Nature Photonics, vol. 8, no. 6, pp. 448–454, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Weissleder and U. Mahmood, “Molecular imaging,” Radiology, vol. 219, no. 2, pp. 316–333, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. T. F. Massoud and S. S. Gambhir, “Molecular imaging in living subjects: seeing fundamental biological processes in a new light,” Genes and Development, vol. 17, no. 5, pp. 545–580, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. A. H. Hielscher, “Optical tomographic imaging of small animals,” Current Opinion in Biotechnology, vol. 16, no. 1, pp. 79–88, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. V. Ntziachristos, “Fluorescence molecular imaging,” Annual Review of Biomedical Engineering, vol. 8, pp. 1–33, 2006. View at Google Scholar
  23. F. Leblond, S. C. Davis, P. A. Valdés, and B. W. Pogue, “Pre-clinical whole-body fluorescence imaging: review of instruments, methods and applications,” Journal of Photochemistry and Photobiology B: Biology, vol. 98, no. 1, pp. 77–94, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Youn and K.-J. Hong, “In vivo noninvasive small animal molecular imaging,” Osong Public Health and Research Perspectives, vol. 3, no. 1, pp. 48–59, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Bouchard, G. Bouvette, H. Therriault, R. Bujold, C. Saucier, and B. Paquette, “Pre-irradiation of mouse mammary gland stimulates cancer cell migration and development of lung metastases,” British Journal of Cancer, vol. 109, no. 7, pp. 1829–1838, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Lapointe, J. Pichette, and Y. Bérubé-Lauzière, “A multi-view time-domain non-contact diffuse optical tomography scanner with dual wavelength detection for intrinsic and fluorescence small animal imaging,” Review of Scientific Instruments, vol. 83, no. 6, Article ID 063703, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. S. L. Jacques, C. A. Alter, and S. A. Prahl, “Angular dependence of HeNe laser light scattering by human dermis,” Lasers in the Life Sciences, vol. 1, no. 4, pp. 309–333, 1987. View at Google Scholar
  28. W. Cheong, S. Prahl, and A. Welch, “Optical properties of tissues in vitro,” IEEE Journal of Quantum Electronics, vol. 12, no. 12, pp. 2166–2185, 1990. View at Google Scholar
  29. S. K. Sharma and S. Banerjee, “Role of approximate phase functions in Monte Carlo simulation of light propagation in tissues,” Journal of Optics A: Pure and Applied Optics, vol. 5, no. 3, pp. 294–302, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. A. D. Klose and E. W. Larsen, “Light transport in biological tissue based on the simplified spherical harmonics equations,” Journal of Computational Physics, vol. 220, no. 1, pp. 441–470, 2006. View at Publisher · View at Google Scholar · View at Zentralblatt MATH · View at MathSciNet · View at Scopus
  31. J. Bouza-Domínguez and Y. Bérubé-Lauzière, “Diffuse light propagation in biological media by a time-domain parabolic simplified spherical harmonics approximation with ray-divergence effects,” Applied Optics, vol. 49, no. 8, pp. 1414–1429, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Berg, S. Andersson-Engels, and S. Svanberg, Time-Resolved Transillumination Imaging, vol. IS11, SPIE Press, 1993.
  33. J. Pichette, S. Boucher, G. B. Domínguez, and Y. Bérubé-Lauzière, “Diffuse photon density wavefront speed as a contrast for tomographic imaging of heterogeneous diffusive media,” Optics Letters, vol. 39, no. 7, pp. 2097–2100, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Pichette, J. B. Domínguez, and Y. Bérubé-Lauzière, “Time-domain geometrical localization of point-like fluorescence inclusions in turbid media with early photon arrival times,” Applied Optics, vol. 52, no. 24, pp. 5985–5999, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. F. Leblond, H. Dehghani, D. Kepshire, and B. W. Pogue, “Early-photon fluorescence tomography: spatial resolution improvements and noise stability considerations,” Journal of the Optical Society of America A, vol. 26, no. 6, pp. 1444–1457, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. N. Valim, J. Brock, and M. Niedre, “Experimental measurement of time-dependant photon scatter for diffuse optical tomography,” Journal of Biomedical Optics, vol. 15, no. 6, Article ID 065006, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. N. Valim, J. Brock, M. Leeser, and M. Niedre, “The effect of temporal impulse response on experimental reduction of photon scatter in time-resolved diffuse optical tomography,” Physics in Medicine and Biology, vol. 58, no. 2, pp. 335–349, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. J. Bouza Domínguez and Y. Bérubé-Lauzière, “Diffuse optical tomographic imaging of biological media by time-dependent parabolic SPN equations: a two-dimensional study,” Journal of Biomedical Optics, vol. 17, no. 8, Article ID 086012, 14 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. W. Becker, A. Bergmann, and C. Biskup, “Multispectral fluorescence lifetime imaging by TCSPC,” Microscopy Research and Technique, vol. 70, no. 5, pp. 403–409, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Biskup, T. Zimmer, L. Kelbauskas et al., “Multi-dimensional fluorescence lifetime and FRET measurements,” Microscopy Research and Technique, vol. 70, no. 5, pp. 442–451, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. W. Becker, The bh TCSPC Handbook, Becker & Hickl GmbH, Berlin, Germany, 5th edition, 2012.
  42. V. Venugopal, J. Chen, M. Barroso, and X. Intes, “Quantitative tomographic imaging of intermolecular FRET in small animals,” Biomedical Optics Express, vol. 3, no. 12, pp. 3161–3175, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. J. R. Lakowicz, Principles of Fluorescence Spectroscopy, Springer, New York, NY, USA, 3rd edition, 2006.
  44. G. Bodi and Y. Bérubé-Lauzière, “A new deconvolution technique for time-domain signals in diffuse optical tomography without a priori information,” in Diffuse Optical Imaging II, vol. 7369 of Proceedings of SPIE, Munich, Germany, July 2009. View at Publisher · View at Google Scholar
  45. M. Diop and K. St Lawrence, “Deconvolution method for recovering the photon time-of-flight distribution from time-resolved measurements,” Optics Letters, vol. 37, no. 12, pp. 2358–2360, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. B. W. Pogue, T. O. McBride, U. L. Osterberg, and K. D. Paulsen, “Comparison of imaging geometries for diffuse optical tomography of tissue,” Optics Express, vol. 4, no. 8, pp. 270–286, 1999. View at Publisher · View at Google Scholar · View at Scopus
  47. U. J. Netz, J. Beuthan, and A. H. Hielscher, “Multipixel system for gigahertz frequency-domain optical imaging of finger joints,” Review of Scientific Instruments, vol. 79, no. 3, Article ID 034301, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. PerkinElmer's large product line of preclinical small animal optical imaging systems (IVIS R series, MaestroTM, and FMT 2500TM LX), PerkinElmer of Caliper Life Sciences, Xenogen Corp, Cambridge Research Instruments (CRi), and VisEn Medical, http://www.perkinelmer.com/.
  49. Biospace Lab, PhotonIMAGER, http://www.biospacelab.com/.
  50. N. Zarif Yussefian, M. Letendre-Janiaux, and Y. Bérubé-Lauzière, “Continuous wave optical scanner for small animal optical molecular imaging,” in Biomedical Optics Topical Meeting (OSA-BIOMED), BM3A–55, Optical Society of America, 2014. View at Google Scholar
  51. R. Lebel, N. Zarifyussefian, M. Letendre-Jauniaux et al., “Ultra-high sensitivity detection of bimodal probes at ultra-low noise for combined fluorescence and positron emission tomography imaging,” in Multimodal Biomedical Imaging VIII, vol. 8574 of Proceedings of SPIE, p. 7, SPIE BiOS—Photonics West, San Francisco, Calif, USA, February 2013. View at Publisher · View at Google Scholar
  52. J. A. Guggenheim, H. R. A. Basevi, J. Frampton, I. B. Styles, and H. Dehghani, “Multi-modal molecular diffuse optical tomography system for small animal imaging,” Measurement Science and Technology, vol. 24, no. 10, Article ID 105405, 2013. View at Publisher · View at Google Scholar · View at Scopus
  53. A. Koenig, A. Planat-Chrétien, K. Hassler et al., “Validation of an xct/fdot system on mice,” ISRN Optics, vol. 2012, Article ID 735231, 13 pages, 2012. View at Publisher · View at Google Scholar
  54. M. L. Flexman, F. Vlachos, H. K. Kim et al., “Monitoring early tumor response to drug therapy with diffuse optical tomography,” Journal of Biomedical Optics, vol. 17, no. 1, Article ID 016014, 2012. View at Publisher · View at Google Scholar · View at Scopus
  55. Y. Lin, W. C. Barber, J. S. Iwanczyk, W. Roeck, O. Nalcioglu, and G. Gulsen, “Quantitative fluorescence tomography using a combined tri-modality FT/DOT/XCT system,” Optics Express, vol. 18, no. 8, pp. 7835–7850, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. J. M. Masciotti, J. Lee, M. Stewart, and A. H. Hielscher, “Instrumentation for simultaneous magnetic resonance and optical tomographic imaging of the rodent brain,” in Multimodal Biomedical Imaging IV, vol. 7171 of Proceedings of SPIE, p. 16, San Jose, Calif, USA, February 2009. View at Publisher · View at Google Scholar
  57. L. Hervé, A. Koenig, A. Da Silva et al., “Noncontact fluorescence diffuse optical tomography of heterogeneous media,” Applied Optics, vol. 46, no. 22, pp. 4896–4906, 2007. View at Publisher · View at Google Scholar · View at Scopus
  58. N. Deliolanis, T. Lasser, D. Hyde, A. Soubret, J. Ripoll, and V. Ntziachristos, “Free-space fluorescence molecular tomography utilizing 360° geometry projections,” Optics Letters, vol. 32, no. 4, pp. 382–384, 2007. View at Publisher · View at Google Scholar · View at Scopus
  59. R. B. Schulz, G. Echner, H. Ruhle et al., “Development of a fully rotational non-contact fluorescence tomographer for small animals,” in Proceedings of the IEEE Nuclear Science Symposium Conference Record, vol. 4, pp. 2391–2393, Fajardo, Puerto Rico, October 2005. View at Publisher · View at Google Scholar · View at Scopus
  60. V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, “Fluorescence molecular tomography resolves protease activity in vivo,” Nature Medicine, vol. 8, no. 7, pp. 757–760, 2002. View at Publisher · View at Google Scholar · View at Scopus
  61. J. H. Lee, H. K. Kim, C. Chandhanayingyong, F. Y.-I. Lee, and A. H. Hielscher, “Non-contact small animal fluorescence imaging system for simultaneous multi-directional angular-dependent data acquisition,” Biomedical Optics Express, vol. 5, no. 7, pp. 2301–2316, 2014. View at Publisher · View at Google Scholar · View at Scopus
  62. Y. Lin, M. T. Ghijsen, H. Gao, N. Liu, O. Nalcioglu, and G. Gulsen, “A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging,” Physics in Medicine and Biology, vol. 56, no. 15, pp. 4731–4747, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. C. D. Darne, Y. Lu, I.-C. Tan et al., “A compact frequency-domain photon migration system for integration into commercial hybrid small animal imaging scanners for fluorescence tomography,” Physics in Medicine and Biology, vol. 57, no. 24, pp. 8135–8152, 2012. View at Publisher · View at Google Scholar · View at Scopus
  64. J. C. Rasmussen, A. Joshi, T. Pan, T. Wareing, J. McGhee, and E. M. Sevick-Muraca, “Radiative transport in fluorescence-enhanced frequency domain photon migration,” Medical Physics, vol. 33, no. 12, pp. 4685–4700, 2006. View at Publisher · View at Google Scholar · View at Scopus
  65. Y. Lu, C. D. Darne, I. C. Tan et al., “Experimental comparison of continuous-wave and frequency-domain fluorescence tomography in a commercial multi-modal scanner,” IEEE Transactions on Medical Imaging, vol. 34, no. 6, pp. 1197–1211, 2015. View at Publisher · View at Google Scholar
  66. B. Montcel and P. Poulet, “An instrument for small-animal imaging using time-resolved diffuse and fluorescence optical methods,” Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 569, no. 2, pp. 551–556, 2006. View at Publisher · View at Google Scholar · View at Scopus
  67. D. Kepshire, N. Mincu, M. Hutchins et al., “A microcomputed tomography guided fluorescence tomography system for small animal molecular imaging,” Review of Scientific Instruments, vol. 80, no. 4, Article ID 043701, 2009. View at Publisher · View at Google Scholar · View at Scopus
  68. M. J. Niedre, G. M. Turner, and V. Ntziachristos, “Time-resolved imaging of optical coefficients through murine chest cavities,” Journal of Biomedical Optics, vol. 11, no. 6, Article ID 064017, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Niedre and V. Ntziachristos, “Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons,” Optics Letters, vol. 35, no. 3, pp. 369–371, 2010. View at Publisher · View at Google Scholar · View at Scopus
  70. R. E. Nothdurft, S. V. Patwardhan, W. Akers, Y. Ye, S. Achilefu, and J. P. Culver, “In vivo fluorescence lifetime tomography,” Journal of Biomedical Optics, vol. 14, no. 2, Article ID 024004, 2009. View at Publisher · View at Google Scholar · View at Scopus
  71. A. T. N. Kumar, S. B. Raymond, A. K. Dunn, B. J. Bacskai, and D. A. Boas, “A time domain fluorescence tomography system for small animal imaging,” IEEE Transactions on Medical Imaging, vol. 27, no. 8, pp. 1152–1163, 2008. View at Publisher · View at Google Scholar · View at Scopus
  72. D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Optics Letters, vol. 30, no. 11, pp. 1354–1356, 2005. View at Publisher · View at Google Scholar · View at Scopus
  73. V. Venugopal, J. Chen, F. Lesage, and X. Intes, “Full-field time-resolved fluorescence tomography of small animals,” Optics Letters, vol. 35, no. 19, pp. 3189–3191, 2010. View at Publisher · View at Google Scholar · View at Scopus
  74. V. Venugopal, J. Chen, and X. Intes, “Development of an optical imaging platform for functional imaging of small animals using wide-field excitation,” Biomedical Optics Express, vol. 1, no. 1, pp. 143–156, 2010. View at Publisher · View at Google Scholar · View at Scopus
  75. S. R. Arridge, “Optical tomography in medical imaging,” Inverse Problems, vol. 15, no. 2, pp. R41–R93, 1999. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus
  76. W. Becker, Advanced Time-Correlated Single Photon Counting Techniques, Springer, New York, NY, USA, 1st edition, 2005.
  77. J. Pichette, Imagerie de fluorescence et intrinsèque de milieux diffusants par temps d'arrivée des premiers photons [Ph.D. thesis], Université de Sherbrooke, 2014.
  78. Y. Bérubé-Lauzière and V. Robichaud, “Time-resolved fluorescence measurements for diffuse optical tomography using ultrafast time-correlated single photon counting,” in Advanced Photon Counting Techniques, W. Becker, Ed., vol. 6372 of Proceedings of SPIE, Boston, Mass, USA, October 2006. View at Publisher · View at Google Scholar
  79. A. Gulinatti, I. Rech, P. Maccagnani, M. Ghioni, and S. Cova, “Large-area avalanche diodes for picosecond time-correlated photon counting,” in Proceedings of the 35th European Solid-State Device Research Conference (ESSDERC '05), pp. 355–358, Grenoble, France, September 2005. View at Publisher · View at Google Scholar · View at Scopus
  80. S. Cova, M. Ghioni, F. Zappa, I. Rech, and A. Gulinatti, “A view on progress of silicon single-photon avalanche diodes and quenching circuits,” in Proceedings of the Advanced Photon Counting Techniques, vol. 6372 of Proceedings of SPIE, The International Society for Optical Engineering, Boston, Mass, USA, October 2006. View at Publisher · View at Google Scholar
  81. C. Cammi, F. Panzeri, A. Gulinatti, I. Rech, and M. Ghioni, “Custom single-photon avalanche diode with integrated front-end for parallel photon timing applications,” Review of Scientific Instruments, vol. 83, no. 3, Article ID 033104, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  82. M. Crotti, I. Rech, and M. Ghioni, “Four channel, 40 ps resolution, fully integrated time-to-amplitude converter for time-resolved photon counting,” IEEE Journal of Solid-State Circuits, vol. 47, no. 3, pp. 699–708, 2012. View at Publisher · View at Google Scholar · View at Scopus
  83. S. Antonioli, L. Miari, A. Cuccato, M. Crotti, I. Rech, and M. Ghioni, “8-channel acquisition system for time-correlated single-photon counting,” Review of Scientific Instruments, vol. 84, no. 6, Article ID 064705, 2013. View at Publisher · View at Google Scholar · View at Scopus
  84. R. Yao, Q. Pian, and X. Intes, “Wide-field fluorescence molecular tomography with compressive sensing based preconditioning,” Biomedical Optics Express, vol. 6, no. 12, pp. 4887–4898, 2015. View at Publisher · View at Google Scholar
  85. A. Goetzberger, B. Mcdonald, R. H. Haitz, and R. M. Scarlett, “Avalanche effects in silicon p−n junctions. II. Structurally perfect junctions,” Journal of Applied Physics, vol. 34, no. 6, pp. 1591–1600, 1963. View at Publisher · View at Google Scholar · View at Scopus
  86. R. H. Haitz, “Model for the electrical behavior of a microplasma,” Journal of Applied Physics, vol. 35, no. 5, pp. 1370–1376, 1964. View at Publisher · View at Google Scholar · View at Scopus
  87. R. H. Haitz, “Mechanisms contributing to the noise pulse rate of avalanche diodes,” Journal of Applied Physics, vol. 36, no. 10, pp. 3123–3131, 1965. View at Publisher · View at Google Scholar · View at Scopus
  88. M. Ghioni, S. Cova, A. Lacaita, and G. Ripamonti, “New silicon epitaxial avalanche diode for single-photon timing at room temperature,” Electronics Letters, vol. 24, no. 24, pp. 1476–1477, 1988. View at Publisher · View at Google Scholar · View at Scopus
  89. S. Cova, A. Lacaita, M. Ghioni, G. Ripamonti, and T. A. Louis, “20-ps timing resolution with single-photon avalanche diodes,” Review of Scientific Instruments, vol. 60, no. 6, pp. 1104–1110, 1989. View at Publisher · View at Google Scholar · View at Scopus
  90. A. Lacaita, M. Ghioni, and S. Cova, “Double epitaxy improves single-photon avalanche diode performance,” Electronics Letters, vol. 25, no. 13, pp. 841–843, 1989. View at Publisher · View at Google Scholar · View at Scopus
  91. A. Lacaita, S. Cova, M. Ghioni, and F. Zappa, “Single-photon avalanche diode with ultrafast pulse response free from slow tails,” IEEE Electron Device Letters, vol. 14, no. 7, pp. 360–362, 1993. View at Publisher · View at Google Scholar · View at Scopus
  92. A. Spinelli, M. A. Ghioni, S. D. Cova, and L. M. Davis, “Avalanche detector with ultraclean response for time-resolved photon counting,” IEEE Journal of Quantum Electronics, vol. 34, no. 5, pp. 817–821, 1998. View at Publisher · View at Google Scholar · View at Scopus
  93. M. Ghioni, A. Gulinatti, I. Rech, P. Maccagnani, and S. Cova, “Large-area low-jitter silicon single photon avalanche diodes,” in Quantum Sensing and Nanophotonic Devices V, vol. 6900 of Proceedings of SPIE, International Society for Optical Engineering, San Jose, Calif, USA, February 2008. View at Publisher · View at Google Scholar
  94. C. Cammi, A. Gulinatti, I. Rech, F. Panzeri, and M. Ghioni, “SPAD array module for multi-dimensional photon timing applications,” Journal of Modern Optics, vol. 59, no. 2, pp. 131–139, 2012. View at Publisher · View at Google Scholar · View at Scopus
  95. C. Veerappan, J. Richardson, R. Walker et al., “A 160x128 single-photon image sensor with on-pixel 55ps 10b time-to-digital converter,” in Proceedings of the IEEE International Solid-State Circuits Conference Digest of Technical Papers (ISSCC '11), pp. 312–314, San Francisco, Calif, USA, February 2011.
  96. D. Tyndall, B. R. Rae, D. D. Li et al., “A high-throughput time-resolved mini-silicon photomultiplier with embedded fluorescence lifetime estimation in 0.13 μm cmos,” IEEE Transactions on Biomedical Circuits and Systems, vol. 6, no. 6, pp. 562–570, 2012. View at Google Scholar
  97. F. Villa, B. Markovic, S. Bellisai et al., “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics Journal, vol. 4, no. 3, pp. 795–804, 2012. View at Google Scholar
  98. D. Stoppa, F. Borghetti, J. Richardson et al., “A 32×32-pixel array with in-pixel photon counting and arrival time measurement in the analog domain,” in Proceedings of the 35th European Solid-State Circuits Conference (ESSCIRC '09), pp. 204–207, Athens, Greece, September 2009. View at Publisher · View at Google Scholar · View at Scopus
  99. C. Niclass, C. Favi, T. Kluter, M. Gersbach, and E. Charbon, “A 128×128 single-photon image sensor with column-level 10-bit time-to-digital converter array,” IEEE Journal of Solid-State Circuits, vol. 43, no. 12, pp. 2977–2989, 2008. View at Publisher · View at Google Scholar · View at Scopus
  100. M. Ghioni, A. Gulinatti, P. Maccagnani, I. Rech, and S. Cova, “Planar silicon SPADs with 200-μm diameter and 35-ps photon timing resolution,” in Proceedings of the Single Photon Avalanche Detectors and Superconducting Detectors II, vol. 6372 of Proceedings of SPIE, Advanced Photon Counting Techniques, The International Society for Optical Engineering, Boston, Mass, USA, October 2006. View at Publisher · View at Google Scholar
  101. A. Gulinatti, I. Rech, F. Panzeri et al., “New silicon SPAD technology for enhanced red-sensitivity, high-resolution timing and system integration,” Journal of Modern Optics, vol. 59, no. 17, pp. 1489–1499, 2012. View at Publisher · View at Google Scholar · View at Scopus
  102. S. Cova, M. Ghioni, A. Lacaita, C. Samori, and F. Zappa, “Avalanche photodiodes and quenching circuits for single-photon detection,” Applied Optics, vol. 35, no. 12, pp. 1956–1976, 1996. View at Publisher · View at Google Scholar · View at Scopus
  103. A. Gallivanoni, I. Rech, and M. Ghioni, “Progress in quenching circuits for single photon avalanche diodes,” IEEE Transactions on Nuclear Science, vol. 57, no. 6, pp. 3815–3826, 2010. View at Publisher · View at Google Scholar · View at Scopus
  104. A. Spinelli and A. L. Lacaita, “Physics and numerical simulation of single photon avalanche diodes,” IEEE Transactions on Electron Devices, vol. 44, no. 11, pp. 1931–1943, 1997. View at Publisher · View at Google Scholar · View at Scopus
  105. A. Gulinatti, P. Maccagnani, I. Rech, M. Ghioni, and S. Cova, “35 ps time resolution at room temperature with large area single photon avalanche diodes,” Electronics Letters, vol. 41, no. 5, pp. 272–274, 2005. View at Publisher · View at Google Scholar · View at Scopus
  106. M. Crotti, I. Rech, A. Gulinatti, and M. Ghioni, “Avalanche current read-out circuit for low-jitter parallel photon timing,” Electronics Letters, vol. 49, no. 16, pp. 1017–1018, 2013. View at Publisher · View at Google Scholar · View at Scopus
  107. M. Crotti, I. Rech, and M. Ghioni, “Monolithic time-to-amplitude converter for TCSPC applications with 45 ps time resolution,” in Proceedings of the 7th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME '11), pp. 21–24, Trento, Italy, July 2011. View at Publisher · View at Google Scholar · View at Scopus
  108. M. Kanoun, Y. Bérubé-Lauzière, and R. Fontaine, “High precision time-to-amplitude converter for diffuse optical tomography applications,” in Proceedings of the IEEE International Conference on Design and Technology of Integrated Systems in Nanoscale Era (DTIS '08), pp. 1–4, IEEE, Tozeur, Tunisia, March 2008. View at Publisher · View at Google Scholar · View at Scopus
  109. B. Markovic, S. Tisa, F. A. Villa, A. Tosi, and F. Zappa, “A high-linearity, 17 ps precision time-to-digital converter based on a single-stage Vernier delay loop fine interpolation,” IEEE Transactions on Circuits and Systems. I. Regular Papers, vol. 60, no. 3, pp. 557–569, 2013. View at Publisher · View at Google Scholar · View at MathSciNet · View at Scopus
  110. J. Richardson, R. Walker, L. Grant et al., “A 32×32 50ps resolution 10 bit time to digital converter array in 130nm CMOS for time correlated imaging,” in Proceedings of the IEEE Custom Integrated Circuits Conference (CICC '09), pp. 77–80, San Jose, Calif, USA, September 2009. View at Publisher · View at Google Scholar · View at Scopus
  111. A. Cuccato, S. Antonioli, M. Crotti et al., “Complete and compact 32-channel system for time-correlated single-photon counting measurements,” IEEE Photonics Journal, vol. 5, no. 5, 14 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  112. M. Crotti, I. Rech, and M. Ghioni, “Note: fully integrated time-to-amplitude converter in Si-Ge technology,” Review of Scientific Instruments, vol. 81, no. 10, Article ID 106103, 2010. View at Publisher · View at Google Scholar · View at Scopus
  113. C. Cottini, E. Gatti, and V. Svelto, “A new method for analog to digital conversion,” Nuclear Instruments and Methods, vol. 24, pp. 241–242, 1963. View at Publisher · View at Google Scholar
  114. S. Antonioli, M. Crotti, A. Cuccato, I. Rech, and M. Ghioni, “Time-correlated single-photon counting system based on a monolithic time-to-amplitude converter,” Journal of Modern Optics, vol. 59, no. 17, pp. 1512–1524, 2012. View at Publisher · View at Google Scholar · View at Scopus
  115. F.-J. Luo, Y.-S. Yin, S.-Q. Liang, and M.-L. Gao, “Current switch driver and current source designs for high-speed current-steering DAC,” in Proceedings of the 2nd International Conference on Anti-counterfeiting, Security and Identification (ASID '08), pp. 364–367, IEEE, Guiyang, China, August 2008. View at Publisher · View at Google Scholar · View at Scopus
  116. I. Benamrane and Y. Savaria, “Design techniques for high speed current steering DACs,” in Proceedings of the IEEE North-East Workshop on Circuits and Systems (NEWCAS '07), pp. 1485–1488, Montreal, Canada, August 2007. View at Publisher · View at Google Scholar · View at Scopus
  117. Y. Bérubé-Lauzière, V. Robichaud, and É. Lapointe, “Time-resolved non-contact fluorescence diffuse optical tomography measurements with ultra-fast time-correlated single photon counting avalanche photodiodes,” in Diffuse Optical Imaging of Tissue, vol. 6629 of Proceedings of SPIE, p. 8, Munich, Germany, July 2007. View at Publisher · View at Google Scholar
  118. L. Spinelli, D. Contini, R. Cubeddu et al., “Brain functional imaging at small source-detector distances based on fast-gated single-photon avalanche diodes,” in Photonic Therapeutics and Diagnostics V, vol. 7161 of Proceedings of SPIE, p. 7, San Jose, Calif, USA, January 2009. View at Publisher · View at Google Scholar
  119. A. Tosi, A. Dalla Mora, F. Zappa et al., “Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements,” Optics Express, vol. 19, no. 11, pp. 10735–10746, 2011. View at Publisher · View at Google Scholar · View at Scopus
  120. M. Mazurenka, A. Jelzow, H. Wabnitz et al., “Non-contact time-resolved diffuse reflectance imaging at null source-detector separation,” Optics Express, vol. 20, no. 1, pp. 283–290, 2012. View at Publisher · View at Google Scholar · View at Scopus
  121. Y. Mu, N. Valim, and M. Niedre, “Evaluation of a fast single-photon avalanche photodiode for measurement of early transmitted photons through diffusive media,” Optics Letters, vol. 38, no. 12, pp. 2098–2100, 2013. View at Publisher · View at Google Scholar · View at Scopus