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Journal of Spectroscopy
Volume 2017 (2017), Article ID 3595078, 9 pages
https://doi.org/10.1155/2017/3595078
Research Article

Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model

1Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of Korea
2Advanced Photonics Research Institute, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of Korea
3School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagiro, Bukgu, Gwangju 61005, Republic of Korea

Correspondence should be addressed to Sang-Youp Yim; rk.ca.tsig@miys and Jae Gwan Kim; rk.ca.tsig@mikeaj

Received 11 February 2017; Revised 17 May 2017; Accepted 23 May 2017; Published 16 July 2017

Academic Editor: Yusuke Oshima

Copyright © 2017 Myeongsu Seong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The cancer field effect (CFE) has been highlighted as one of indirect indications for tissue variations that are insensitive to conventional diagnostic techniques. In this research, we had a hypothesis that chemotherapy for breast cancer would affect skin biochemical compositions that would be reflected by Raman spectral changes. We used a fiber-optic probe-based Raman spectroscopy to perform preliminary animal experiments to validate the hypothesis. Firstly, we verified the probing depth of the fiber-optic probe (~800 μm) using a simple intravenous fat emulsion-filled phantom having a silicon wafer at the bottom inside a cuvette. Then, we obtained Raman spectra during breast cancer treatment by chemotherapy from a small animal model in longitudinal manner. Our results showed that the treatment causes variations of biochemical compositions in the skin. For further validation, the Raman spectra will have to be collected from more populations and spectra will need to be compared with immunohistochemistry of the breast tissue.