Research Article
Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry
Table 1
Composition of calibration and validation samples.
| | Concentration level | 1 | 2 | 3 | 4 | 5 | | 80% | 90% | 100% | 110% | 120% |
| | Paracetamol | 38.71 | 43.55 | 48.39 | 53.23 | 58.06 | | Caffeine | 3.84 | 4.35 | 4.84 | 5.32 | 5.81 |
| | | Tablets composition (mg/tablet) | | Paracetamol | 240.0 | 270.0 | 300.0 | 330.0 | 360.0 | | Caffeine | 24.0 | 27.0 | 30.0 | 33.0 | 36.0 | | Lactose | 146.0 | 113.0 | 80.0 | 47.0 | 14.0 | | Cornstarch | 210.0 | 210.0 | 210.0 | 210.0 | 210.0 | | Colloidal silicon dioxide | | PVP | | Talcum | | Magnesium stearate |
| | Tablet weight | 620.0 | 620.0 | 620.0 | 620.0 | 620.0 |
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Calibration samples: levels 1, 2, 3, 4, and 5. Validation samples: levels 2, 3, and 4.
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