Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

Table 2

Experimental design matrix for calibration set.

Exp; name	Run; order	X1	X2	Exp; name	Run; order	X1	X2
N1	9	38.71	3.87	N15	13	58.06	4.84
N2	26	43.55	3.87	N16	25	38.71	5.32
N3	16	48.39	3.87	N17	24	43.55	5.32
N4	21	53.23	3.87	N18	17	48.39	5.32
N5	11	58.06	3.87	N19	4	53.23	5.32
N6	15	38.71	4.35	N20	7	58.06	5.32
N7	8	43.55	4.35	N21	28	38.71	5.81
N8	6	48.39	4.35	N22	1	43.55	5.81
N9	27	53.23	4.35	N23	3	48.39	5.81
N10	23	58.06	4.35	N24	18	53.23	5.81
N11	14	38.71	4.84	N25	22	58.06	5.81
N12	20	43.55	4.84	N26	12	48.39	4.84
N13	2	48.39	4.84	N27	19	48.39	4.84
N14	10	53.23	4.84	N28	5	58.06	4.84

X₁—paracetamol concentration (mg/tablet); X₂—caffeine concentration (mg/tablet). Validation samples.