Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

Table 5

Paracetamol and caffeine determination by NIR-validated method and HPLC reference method.

API	Paracetamol		Caffeine
Method	NIR	HPLC	NIR	HPLC
Theoretic concentration (mg)	48.39	48.39	4.839	4.839
Found (mg)	48.43	48.82	4.810	4.674
Recovery (%)	100.08	100.89	99.40	96.59
CV	0.17	1.19	2.15	4.53
t value	1.186		1.865
value	0.236		0.0915