Table of Contents
Journal of Signal Transduction
Volume 2010, Article ID 985132, 7 pages
http://dx.doi.org/10.1155/2010/985132
Review Article

Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases Are Essential for the Inflammatory Response in Cancer Cells

Jun Sun1,2,3

1Gastroenterology & Hepatology Division, Department of Medicine, University of Rochester, Box 646, 601 Elmwood Avenue, Rochester, NY 14642, USA
2Department of Microbiology and Immunology, University of Rochester, Box 646, 601 Elmwood Avenue, Rochester, NY 14642, USA
3James Wilmot Cancer Center, University of Rochester, Box 646, 601 Elmwood Avenue, Rochester, NY 14642, USA

Received 9 March 2010; Accepted 16 June 2010

Academic Editor: Hiroshi Shibuya

Copyright © 2010 Jun Sun. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inflammation plays a critical role in the development of cancer. Matrix Metalloproteinase (MMP) functions in the remodeling of the extracellular matrix that is integral for many normal and pathological processes such as morphogenesis, angiogenesis, tissue repair, and tumor invasion. The tissue inhibitor of metalloproteinases (TIMPs) family regulates the activity of multifunctional metalloproteinases. In this paper, we discuss the role and mechanism of MMP and TIMP in regulating inflammation responses in solid tumors. We discuss the mechanism of MMP and inflammation in melanoma, colon cancer, breast cancer, and prostate cancer. We highlight the roles of the TIMP-2 in modulating the proinflammatory NF- B pathway in melanoma and lung caner cells. Based on the molecular mechanisms of TIMPs and MMPs in inflammation and cancer, we can design new strategies for cancer therapy.