Journal of Signal Transduction

Review Article

Itk: The Rheostat of the T Cell Response

Table 1

Comparison of phenotypes between TCR-inducible signaling molecules. Table depicting developmental, biochemical, and phenotypic defects observed in mice deficient for the indicated gene in the first column. A “Yes” response denotes confirmation of the defect, while “N.A.” indicates “not applicable” and “N.D.” indicates “not determined”. References for the defects are listed in the last column.
Developmental defectsBiochemical defectsIn vivo phenotype defectsRef.
KO mouseStage pre- TCRAffectedPLCγl phosCa++ fluxErk phosNFAT activIL-2 prodProliferationActin polymAdhesionActivated phenotypeAICDTH2 responsePathogen clearanceEosinophilia
ItkMildDP-SPYesMildYesYesYesMildYesYesYesYesYesYesMild[36, 92, 167, 170, 202, 204, 205]
RIkNoNoNoNoNoNoMildNoNoNoN.D.N.D.N.D.N.D.N.D.[92]
TecNoNoN.D.N.D.N.D.N.D.NoNoN.D.N.D.N.D.N.D.N.D.N.D.N.D.[144]
Itk/RlkYesDP-SPYesYesYesYesYesYesYesYesYesYesNoNoN.D.[92]
LckYesDN1YesYesYesYesYesYesYesN.D.N.A.N.A.N.A.N.A.N.A.[141]
ZAP-70YesDN3-DN4YesYesYesYesYesYesYesN.D.N.A.N.A.N.A.N.A.N.A.[142, 143]
LAT Y136FYesDN3-DN4YesYesNoYesYesYesYesYesYesYesIncreaseN.D.Yes[145–147]
SLP-76YesDN1YesYesYesYesN.D.YesYesN.D.N.A.N.A.N.A.N.A.N.A.[148, 149]
Vav1MildDP-SPYesYesYesYesYesYesYesYesN.D.N.D.YesN.D.N.D.[107, 108, 158–162]
ItpkBYesDP-SPYesNoYesN.D.N.D.N.D.N.D.N.D.N.D.N.D.N.D.N.D.N.D.[49, 163, 164]
GadsYesDN3-DN4YesYesYesYesYesYesN.D.N.D.N.D.N.D.N.D.N.D.N.D.[165]
PLCγlMildDP-SPYesYesN.D.YesYesYesN.D.N.D.N.D.N.D.N.D.N.D.N.D.[150]
WASpMildNoN.D.MildNoYesYesYesYesNoYesN.D.YesN.D.N.D.[151, 152]
PKCθNoNoYesYesNoYesYesYesYesN.D.N.D.YesYesYesN.D.[153–157]
CypANoNoNoNoNoYesYesYesN.D.N.D.N.D.N.D.YesN.D.N.D.[66, 166]