Table of Contents
Journal of Signal Transduction
Volume 2011 (2011), Article ID 603290, 11 pages
http://dx.doi.org/10.1155/2011/603290
Review Article

Functional Diversity of the Schistosoma mansoni Tyrosine Kinases

1Grupo de Genômica e Biologia Computacional, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz - FIOCRUZ, 30190-002 Belo Horizonte, MG, Brazil
2Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais - UFMG, 31270-910 Belo Horizonte, MG, Brazil
3Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz - FIOCRUZ, 30190-002 Belo Horizonte, MG, Brazil
4Centro de Excelência em Bioinformática, Fundação Oswaldo Cruz - FIOCRUZ, 30190-110 Belo Horizonte, MG, Brazil

Received 2 December 2010; Revised 15 February 2011; Accepted 15 March 2011

Academic Editor: Karl Matter

Copyright © 2011 Lívia G. A. Avelar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Schistosoma mansoni, one of the causative agents of schistosomiasis, has a complex life cycle infecting over 200 million people worldwide. Such a successful and prolific parasite life cycle has been shown to be dependent on the adaptive interaction between the parasite and hosts. Tyrosine kinases (TKs) play a key role in signaling pathways as demonstrated by a large body of experimental work in eukaryotes. Furthermore, comparative genomics have allowed the identification of TK homologs and provided insights into the functional role of TKs in several biological systems. Finally, TK structural biology has provided a rational basis for obtaining selective inhibitors directed to the treatment of human diseases. This paper covers the important aspects of the phospho-tyrosine signaling network in S. mansoni, Caenorhabditis elegans, and humans, the main process of functional diversification of TKs, that is, protein-domain shuffling, and also discusses TKs as targets for the development of new anti-schistosome drugs.