Functional Diversity of the Schistosoma mansoni Tyrosine Kinases

Figure 1

S. mansoni phosphotyrosine-signaling network. In the phosphotyrosine signaling pathway, the tyrosine kinase (TK), phosphotyrosine phosphatase (PTP), and Src Homology 2 (SH2) domains form a highly interdependent signaling network. At the moment, 81 protein members of the phosphotyrosine signaling network on S. mansoni genome were identified. This signaling network serves as the “writer”, “eraser”, and “reader” domains, respectively, for processing phosphotyrosine targets.