Table of Contents
Journal of Signal Transduction
Volume 2011 (2011), Article ID 768512, 8 pages
http://dx.doi.org/10.1155/2011/768512
Review Article

Erk in Kidney Diseases

1Division of Nephrology, Department of Medicine, O'Brien Kidney Research Center, University of Texas Health Science Center, San Antonio, TX 78229, USA
2South Texas Veterans Health Care System, San Antonio, TX 78229, USA

Received 7 October 2010; Accepted 1 February 2011

Academic Editor: Peter P. Ruvolo

Copyright © 2011 Denis Feliers and Balakuntalam S. Kasinath. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acute or chronic kidney injury results from various insults and pathological conditions, and is accompanied by activation of compensatory repair mechanisms. Both insults and repair mechanisms are initiated by circulating factors, whose cellular effects are mediated by activation selective signal transduction pathways. Two main signal transduction pathways are activated during these processes, the phosphatidylinositol 3 kinase (PI-3K)/mammalian target of rapamycin (mTOR) and the mitogen-activated protein kinase (MAPK) cascades. This review will focus on the latter, and more specifically on the role of extracellular signal-regulated kinase (ERK) cascade in kidney injury and repair.