Fish Suppressors of Cytokine Signaling (SOCS): Gene Discovery, Modulation of Expression and Function

Table 1

Amino acid identities (top right) and similarities (bottom left) of the fish CISHa and b molecules and CISH molecules from birds, amphibians, and mammals. The accession numbers of the protein sequences are given in Figure 3.

	aa	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22
(1) Trout-a	225		90.2	97.8	72.0	65.3	64.9	69.0	64.6	53.2	61.1	57.3	56.9	46.2	43.8	49.6	48.1	48.0	38.6	36.8	38.6	40.7	41.5
(2) Salmon-a1	225	94.2		90.7	71.1	68.4	68.0	72.6	67.7	53.0	60.5	55.5	55.0	47.3	43.8	49.3	47.2	49.3	42.7	40.7	40.9	43.0	43.5
(3) Salmon-a2	225	97.8	94.7		72.4	66.7	65.5	70.4	65.9	52.8	61.6	57.3	56.9	45.4	42.5	48.7	47.6	48.4	39.4	37.5	39.4	41.5	42.7
(4) Smelt-a	220	81.8	82.7	82.2		70.4	68.6	72.1	65.9	57.8	61.0	55.1	55.3	45.9	45.4	48.7	45.6	51.1	42.0	40.8	40.5	42.6	40.8
(5) Tetraodon-a	225	81.8	83.6	83.1	84.4		89.8	84.1	76.5	53.3	57.8	51.3	50.4	43.8	45.5	47.6	43.3	45.3	40.5	40.0	39.8	42.2	42.2
(6) Fugu-a	225	78.7	80.4	80.9	82.7	94.7		83.2	78.3	52.2	55.4	52.3	52.3	44.1	44.8	48.0	42.9	44.3	42.0	42.0	40.3	39.5	41.6
(7) Stickleback-a	226	81.9	84.5	83.2	82.7	92.5	89.4		81.4	53.0	58.8	54.6	53.8	43.4	46.3	47.4	43.0	47.3	43.0	41.4	40.8	41.8	42.7
(8) Medaka-a	226	78.8	80.5	80.1	78.3	86.7	86.3	89.8		51.3	55.3	51.2	51.0	43.6	44.8	43.6	42.4	48.7	41.8	41.5	38.6	41.7	40.9
(9) Zebrafish-a	212	66.2	67.1	66.2	70.5	70.7	70.2	69.0	68.6		71.1	49.6	50.0	43.6	45.3	48.4	47.8	49.5	41.1	39.2	41.3	42.6	41.9
(10) gCarp-a	222	75.1	76.9	76.0	76.6	79.6	75.6	75.7	75.7	79.7		54.5	55.0	43.9	44.6	46.4	44.8	51.1	43.4	44.4	43.6	46.6	44.2
(11) Trout-b	233	69.5	67.4	68.7	67.0	68.2	67.4	68.7	68.2	61.4	66.1		98.7	53.8	49.8	54.5	54.0	50.6	44.7	42.9	44.1	46.7	43.5
(12) Sockeye-b	233	69.1	67.0	68.2	67.0	67.8	67.8	68.2	67.8	62.2	66.5	98.7		52.9	49.8	54.5	54.0	50.8	45.2	41.8	44.4	47.1	43.9
(13) Tetraodon-b	214	60.6	60.6	59.7	61.9	62.3	61.9	61.0	61.5	57.6	58.4	66.5	65.2		69.7	58.0	54.1	42.9	39.3	37.4	40.2	37.4	38.8
(14) Fugu-b	214	58.2	58.2	56.9	63.2	63.6	61.8	61.9	58.8	62.1	62.6	63.1	63.1	80.1		60.5	57.4	43.5	37.9	36.4	38.3	38.9	37.9
(15) Stickleback-b	210	60.4	60.4	59.6	61.8	64.4	61.8	63.3	59.7	60.4	61.7	66.1	66.1	69.3	74.8		67.1	50.0	41.8	42.7	42.4	40.9	40.8
(16) Medaka-b	201	62.2	61.8	62.2	60.9	60.9	61.8	62.4	61.9	65.6	60.4	66.1	66.1	67.1	73.4	78.1		47.2	39.2	39.6	39.5	41.0	37.5
(17) Zebrafish-b	204	64.4	64.9	64.9	68.6	65.3	63.1	62.8	62.8	68.4	67.6	63.1	63.1	59.3	60.3	64.3	68.6		38.5	37.7	38.2	39.0	38.4
(18) Human	258	53.5	57.0	53.9	56.2	57.8	58.5	57.0	56.6	53.9	57.0	57.8	58.1	54.3	50.4	53.1	50.0	50.4		90.7	89.9	66.5	56.6
(19) Mouse	257	52.1	54.5	52.5	54.5	56.8	56.8	56.0	56.8	52.1	56.8	56.8	57.2	53.3	49.0	56.0	52.1	50.6	92.2		88.7	66.4	55.8
(20) Cow	254	55.1	55.9	55.5	53.9	58.7	57.1	59.4	55.1	53.1	57.5	57.1	58.7	54.3	50.0	55.1	52.8	51.2	91.5	90.3		65.3	57.0
(21) Chicken	249	59.4	58.2	59.8	56.6	61.0	58.2	57.4	58.6	54.6	60.2	61.4	61.0	56.6	52.2	53.8	53.4	53.8	76.0	75.9	76.8		60.6
(22) Frog	257	54.9	55.6	55.6	53.7	57.2	53.7	56.8	54.1	56.0	56.8	56.0	57.2	54.5	52.9	53.7	52.1	50.2	75.2	73.5	73.2	73.5