Review Article

Fish Suppressors of Cytokine Signaling (SOCS): Gene Discovery, Modulation of Expression and Function

Table 3

Amino acid identities (top right) and similarities (bottom left) of the fish SOCS5a and 5b molecules and SOCS5 molecules from birds, amphibians, and mammals. The accession numbers of the protein sequences are given in Figure 3.

aa1234567891011121314151617

1. Zebrafish-a155762.876.376.376.675.042.743.243.343.041.341.964.164.064.663.160.2
2. Zebrafish-a252876.164.866.364.464.244.542.943.142.743.342.463.163.162.562.260.1
3. Stickleback-a56184.575.687.486.484.842.343.642.443.941.943.265.465.465.963.962.4
4. Medaka-a56184.576.391.183.282.843.342.042.544.443.542.164.464.666.365.162.3
5. Tetraodon-a55983.575.390.487.990.542.542.444.143.140.742.463.463.665.263.861.5
6. Fugu-a55083.876.489.188.193.743.043.043.343.741.443.561.562.063.663.261.4
7. Zebrafish-b49757.559.756.755.857.457.363.763.561.561.661.244.544.845.644.444.8
8. Trout-b54460.760.759.059.558.559.175.074.475.071.572.143.944.945.443.942.8
9. Stickleback-b53360.759.557.858.160.559.376.481.676.573.173.345.445.744.345.444.1
10. Medaka-b54460.959.059.459.458.159.174.384.984.274.673.745.547.145.846.245.3
11. Tetraodon-b54259.859.857.859.556.458.472.780.780.182.488.244.545.646.144.142.1
12. Fugu-b53759.259.059.258.557.659.672.681.681.482.090.844.244.644.943.643.8
13. Human53676.175.475.274.775.175.158.861.463.463.161.462.297.894.691.080.6
14. Cow53675.875.675.474.974.875.559.361.662.363.261.662.299.195.090.980.1
15. Mouse53676.575.975.675.075.176.260.861.863.263.861.862.697.297.889.479.0
16. Chicken53674.375.674.774.375.376.258.661.261.263.160.961.895.194.894.479.7
17. Frog53574.775.574.274.974.175.659.360.163.661.660.362.290.189.689.288.8