Regulation of Adherens Junction Dynamics by Phosphorylation Switches

Table 2

Targets of phosphorylation in AJ.

Gene symbol	Protein name	Phosphorylated residue	Reference
Transmembrane
CDH1	Ecadherin	S/Y	[54, 86, 87]
PVRL1	Nectin	Y	[88]
Cadherin- or membrane bound
CTNNB1	β-catenin	S/T/Y	[16, 89, 90]
EZR, RDX, MSN	ERM proteins (ezrin/radixin/moesin)	S/T/Y	[91–93]
CTNND1	p120-catenin	S/T/Y	[94, 95]
JUP	Gamma-catenin	Y	[96]
PARD3	Partitioning defective 3 homolog	S/T/Y	[97, 98]
Secondary adaptors
CTNNA1	α-catenin	S/T/Y	[99, 100]
VCL	Vinculin	S/Y	[101, 102]
LIMA1	Eplin	S	[103]
VASP	Vasodilator-stimulated phosphoprotein	S/T/Y	[104–106]
SHC1	SHC-transforming protein 1	Y	[107, 108]
Actin and actin regulators
ACTN1	α-actinin	S/Y	[109, 110]
CTTN	Cortactin	S/T/Y	[111, 112]
ACTB	F-actin	S/Y	[113–115]
GTPASE regulators
PI3K	Phospho-inositide-3-kinase	Y	[116]
RAPGEF1	Rap guanine nucleotide exchange factor 1	Y	[117]
ARHGAP35	rho GAP p190A	Y	[118, 119]
ARHGAP32	p200RhoGAP	Y	[120, 121]
TIAM1	T-lymphoma invasion and metastasis-inducing protein 1	Y	[122]
VAV2	Vav 2 guanine nucleotide exchange factor	Y	[122, 123]